The outbreak of coronavirus disease 2019 has become a public health emergency of global concern, posing a great threat to people’s health. As a state-level large-scale general hospital with rich medical rescue experience in dealing with emergent public health events, including severe acute respiratory syndrome and earthquake, West China Hospital of Sichuan University quickly established six working mechanisms for telemedicine. West China Hospital of Sichuan University set up a team of clinicians to provide multi-disciplinary telemedicine consultation, telemedicine education and joint rounds on line with the 5th generation mobile networks, which designed to help estimate patients’ condition, innovate the mode of diagnosis and treatment, and improve service efficiency in remote institutions including preferred hospitals for coronavirus disease 2019 patients in Sichuan Province and telemedicine alliance units outside the province.