ObjectiveTo specify the specific wind environment conditions of the outdoor wind speed field and wind pressure field in Wuhan Huoshenshan Hospital, identify the epidemic prevention area under special conditions such as daily cleaning and disinfection as well as accidents, and provide technical references for epidemic prevention work.MethodsThe network open data were adopted to build 3D models of buildings in Wuhan Huoshenshan Hospital and surrounding areas by using Auto CAD 2008 software, and then PHOENICS 2011 software was used to parameterize settings to simulate winter outdoor wind speed and wind pressure fields, to identify the epidemic prevention area under special conditions such as daily cleaning and disinfection as well as accidents.ResultsIn the prevailing wind direction, the speeds of wind towards the No. 1 building, the intensive care unit and the reception area for confirmed patients transferred by ambulance, the No.2 building, and the temporary storage room of the isolation medical area are 1.0−1.5, 2.5−3.0, 2.0−2.5, and 3.0−3.5 m/s, respectively; the speed of wind towards the living area for medical staff is 2.5 m/s. In the isolation medical area, the pressure difference between the windward side and the leeward side of the building in the first row of the windward side is ≥5 Pa, and those of the rest buildings are ≥0.5 and ≤5 Pa; in the living area for medical staff, the pressure difference between the windward side and the leeward side of the north of the building is ≥5 Pa, while that of the south of the building is ≤0.5 Pa.ConclusionOn the whole, there are areas with poor ventilation and at risk of pollutants gathering in Wuhan Huoshenshan Hospital, so the daily cleaning and disinfection work and epidemic prevention work of accident and other special circumstances should be done well.