ObjectiveTo explore the value of platelet-lymphocyte ratio (PLR) after return of spontaneous circulation (ROSC) combined with Sequential Organ Failure Assessment (SOFA) for estimating the short-term prognosis of ROSC patients suffered from in-hospital cardiac arrest (IHCA).MethodsROSC adult patients who suffered from IHCA during treatment in the Emergency Department of West China Hospital of Sichuan University between 00:00, August 1st, 2010 and 23:59, July 31st, 2018 were included retrospectively. The basic and clinical data of patients were collected. Patients were divided into survival group and death group according to the 28-day prognosis. Through logistic regression and receiver operating characteristic (ROC) curve analysis, the efficacy of PLR after ROSC combined with SOFA score in predicting the 28-day prognosis of IHCA patients was explored.ResultsA total of 199 patients were included, including 135 males and 64 females, with a mean age of (60.45±17.52) years old. There were 154 deaths and 45 survivors within 28 days. There were statistically significant differences between the survival group and the death group in terms of epinephrine dosage, SOFA score, proportion of patients complicated with respiratory diseases, and post-ROSC laboratory indexes including PLR, hemoglobin, red blood cell count, lymphocyte count, indirect bilirubin, serum albumin, cholesterol, and activated partial thrombin time (P<0.05). The result of multivariate logistic regression analysis showed that epinephrine dosage [odds ratio (OR)=1.177, 95% confidence interval (CI) (1.024, 1.352), P=0.022], SOFA score [OR=1.536, 95%CI (1.173, 2.010), P=0.002], PLR after ROSC [OR=1.011, 95%CI (1.004, 1.018), P=0.002] were independent risk factors for ROSC patients’ death on day 28. The areas under the ROC curve of epinephrine dosage, SOFA score and PLR after ROSC were 0.702, 0.703 and 0.737, respectively, to predict the patients’ 28-day outcome. Combining the epinephrine dosage and PLR after ROSC with SOFA score respectively to predict the 28-day outcome of patients, the areas under the ROC curve were 0.768 and 0.813, respectively.ConclusionsThe significant increase of PLR after ROSC is an independent risk factor for death within 28 days after ROSC. The combined application of PLR after ROSC and SOFA score in the 28-day outcome prediction of patients has better predictive efficacy.
ObjectiveTo identify differences in blood routine indicators between lung cancer patients and healthy controls, and between different subgroups of lung cancer patients, so as to improve the early detection of lung cancer prognosis, and provide a basis for risk stratification and prognostic judgment for patients with lung cancer.MethodsThis study enrolled 1 227 patients pathologically diagnosed with lung cancer from December 2008 to December 2013 and 2 454 healthy controls 1∶2 matched by sex and age. The blood routine data of lung cancer patients were collected when they were first diagnosed with lung cancer. Gender and age stratified analysis of blood routine indicators between lung cancer patients and controls were conducted. Comparisons of blood routine indicators among lung cancer patients with different pathological types, stages, and prognosis were performed, followed by Cox regression survival analysis. Normally distributed quantitative variables were presented as mean ± standard deviation and non-normally distributed quantitative variables as medium (lower quartile, upper quartile).ResultsCompared to healthy controls, the counts of platelet [(206.84±80.47) vs. (175.27±55.74)×109/L], white blood cells [(7.04±2.29) vs. (6.08±1.40)×109/L], neutrophil [(4.90±2.08) vs. (3.61±1.07)×109/L], monocyte [0.42 (0.30, 0.54) vs. 0.33 (0.26, 0.42)×109/L], and eosinophil [0.14 (0.07, 0.24) vs. 0.12 (0.07, 0.19)×109/L], as the well as neutrophil-lymphocytes ratio (3.91±2.82 vs. 2.03±0.89) and platelet-lymphocyte ratio (160.35±96.06 vs. 96.93±38.02) in lung cancer patients increased significantly, while the counts of red blood cells [(4.41±0.58) vs. (4.85±0.51)×1012/L] and lymphocyte [(1.49±0.60) vs. (1.93±0.59)×109/L] in lung cancer patients decreased, and the differences were statistically significant (P<0.05). The counts of platelet, red blood cells, white blood cells, neutrophil, and monocyte differed among patients with different pathological types, tumor stages, and prognosis (P<0.05). Neutrophil-lymphocytes ratio and platelet-lymphocyte ratio were higher in squamous cell carcinoma patients than those in other pathological patients, higher in advanced lung cancer patients than those in early stage patients, and higher in dead lung cancer patients than those in survival patients (P<0.05). Neutrophil-lymphocyte ratio was an independent factor affecting the prognosis of lung cancer [hazard ratio=1.077, 95% confidence interval (1.051, 1.103), P<0.001].ConclusionsThe inflammatory index of blood routine indicators are higher in lung cancer patients than those in healthy controls, which indicates that lung cancer is closely related to chronic inflammation. There are significant differences in blood routine inflammation index among lung cancer patients with different pathological types, stages, and prognosis, which reflects the heterogeneity and complexity of lung cancer. Neutrophil-lymphocytes ratio inverse correlates with the prognosis of lung cancer.