Objective To investigate the present situation and effect of public health education based on WeChat platform in a first class of the third grade hospital in Sichuan province. Methods We designed the patient/relative health education questionnaire by literature reading and analysis, and expert consultancy. Then according to the inclusion and exclusion criteria, from April to December 2015, the questionnaire was used to investigate inpatients and their relatives in departments within the WeChat platform including the Department of Endocrinology, International Health Care Center, Department of Gastrointestinal Surgery, Department of Thoracic Surgery, and Department of Dermatovenereology. Results There were 5 WeChat public accounts in the hospital, and the average running days was 177.2, the average number of subscription was 2 974, and the average number of pushed messages was 30. A total of 289 patients/relatives were surveyed, among whom 137 subscribed to the WeChat public account. The investigation results showed that 54.02% of the responders were university or college graduates, most of whom had stable jobs (civil servants: 12.41%, factory workers: 13.87%, medical staff: 9.49%, teachers: 7.30%, IT workers: 6.57%), and had a longer disease course averaging 4.5 years. Among the respondents, 87.59% came to know the WeChat public account through the publicity work by the hospital departments where they stayed, 30.66% thought it was very helpful and 63.50% considered it to be useful, and 47.45% read WeChat messages every day. They admitted that it was convenient and could be found at any time (63.50%, 66.42%), but the drawback was online communication with health educators was not integrated in the platform (54.74%). Conclusions Health education WeChat platform is effective to give health education to the patients and their relatives, but there are also some shortcomings. More functions should be integrated in order to provide comprehensive health education knowledge to the patients.