Pilon fracture is one of the most common and complex fractures in clinic. It has many postoperative complications, such as limitation of motion, pain, swelling, and decreased muscle strength. Complications will seriously affect patients’ ankle function. If the accelerated rehabilitation support can be obtained, patients can obtain a good functional recovery in the later stage. At present, there are few reports on enhanced rehabilitation related to Pilon fractures. This article introduces the rehabilitation treatment protocol for perioperative accelerated rehabilitation of Pilon fractures, mainly including rehabilitation evaluation, preoperative rehabilitation and postoperative rehabilitation treatment, aiming to provide some reference for standardizing the rehabilitation treatment of Pilon fractures in the perioperative period.