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find Author "SHIBin" 3 results
  • Prognostic Signifcance of Visceral Pleural Invasion in 3-5 cm Non-small Cell Lung Cancer

    ObjectiveTo evaluate the prognostic significance of visceral pleural invasion in diameter 3-5 cm nonsmall cell lung cancer(NSCLC). MethodsA total of 112 patients who underwent lobectomy and pathologically diagnosed with NSCLC(3-5 cm) were included in our hospital between January 2006 and December 2010.There were 72 males and 40 females at average age of 61(28-72) years. There were 62 patients diagnosed as adenocarcinoma and 44 as squamous cell lung cancer. Viceral pleural invasion(VPI) was identified in 63 patients as a VPI group. The other 49 patients without VPI were as a NVPI group. All patients were performed with lobectomy and mediastinal lymph node dissection. ResultsThere was no perioperative mortality. More smokers were included in the VPI group when compared with the NVPI group(53.9% vs. 28.6%, P=0.007). More squamous cell cancers were included in the VPI group, while more adenocarcinoma were included in the NVPI group with a statistical difference(P=0.003). The average follow-up duration was 52 months. A total of 32 death occurred at the endpoint. The overall survival(OS) of all included patients was 71.4%. The average follow-up duration was 51 months in the VPI group and 54 months in the NVPI group(P=0.441). There was no statistical difference in OS between the VPI group and the NVPI group(61.7% vs. 83.7%, P=0.017). Cox regression showed age less than 65 years(P=0.007), TNM stage(P=0.013), and VPI(P=0.035) were significant prognostic factors for NSCLC. ConclusionWe identified the presence of VPI as an independent poor prognostic factor in NSCLC patients with diameter at 3-5 cm.

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  • Segmentectomy versus Lobectomy for Non-small Cell Lung Cancer: A Case Control Study

    ObjectiveTo evaluate the safety and efficacy of segmentectomy for early stage non-small cell lung cancer. MethodsWe retrospectively analyzed the clinical data of 88 patients with pulmonary malignant or benign lung tumor who underwent segmentectomy in our hospital between January 2007 and December 2012. There were 45 male and 43 female patients. There were 29 patients in the segmentectomy group and 59 patients in the lobectomy group. Nonsmall cell lung cancer patients underwent segmentectomy were matched with non-small cell lung cancer patients who underwent lobectomy. Perioperative factors and tumor relative prognosis were analyzed. ResultsSegmentectomy were performed in 29 patients in our institution. Average operation time was 210 minutes. Intraoperative blood loss was 166 ml. Postoperative drainage was 2 147 ml. The average extubation duration was 6 days. No significant difference was found in operation time (P>0.999), intraoperative blood loss (P=0.207), postoperative drainage (P=0.946), extubation duration (P=0.804), and postoperative complication (P>0.999) between segmentectomy pulmonary benign disease and segmentectomy lung cancer groups. Compared with lobectomy, segmentectomy showed similar operation time (P=0.462), intraoperative blood loss (P=0.783), extubation duration (P=0.072), complication ratio (P>0.999), and postoperative recurrence/metastasis ratio (P=0.417). While the number of N1 lymph nodes (P=0.033) and N1 station (P=0.024) were fewer in the segmentectomy group than those in the lobectomy group. The overall survival rate (P=0.340) and disease free survival rate (P=0.373) were both comparable between the segmentectomy and the lobectomy group. ConclusionSegmentectomy could be an alternate of lobectomy for patients with selective pulmonary benign disease, and for some early stage non-small cell lung cancer patients with restricted pulmonary function.

    Release date:2016-10-02 04:56 Export PDF Favorites Scan
  • Relationship between Multiple Organ Metastasis and Prognosis for Non-small Cell Lung Cancer

    ObjectiveTo evaluate the prognostic significance of postoperative metastasis in non-small cell lung cancer (NSCLC). MethodsWe retrospectively analyzed the clinical data of 94 patients who underwent curative lobectomy and pathologically diagnosed with NSCLC in our hospital between January 2005 and December 2011. There were 53 males and 41 females with a mean age of 62 (57-76) years. ResultsAmong 94 patients, metastasis occurred during late stage (more than 2 years postoperatively) in 49 (52.12%) patients. Single organ metastasis and multiple organ metastasis were found in 85 (90.43%) patients. The most popular metastatic site was lung (38/94,40.42%), and then bone (27/94,28.72%), and brain (24/94,25.53%). The overall survival (OS) rate of all included patients was 41.5%. The median survival time was 43 months and 29 months for the single metastasis and multiple metastasis groups respectively. There was a statistical difference in OS rate between the single metastasis and multiple metastasis groups (45.9% vs. 0.0%, P<0.001). The median survival time was 50 months and 32 months for early metastatic patients and late metastatic patients respectively. Statistical difference was found in OS rate between the single metastasis and multiple metastasis groups (53.3% vs. 30.6%, Cox P=0.130, Breslow P=0.014). Cox regression showed TNM stage (P=0.003) and single organ metastasis (P<0.001) were significant prognostic factors for NSCLC. ConclusionLung, bone, and brain were the most popular metastatic organs for postoperative NSCLC. The presence of multiple organ metastases can be identified as an independent poor prognostic factor in NSCLC.

    Release date:2016-12-06 05:27 Export PDF Favorites Scan
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