ObjectiveTo summarize the research progress of long noncoding RNA (lncRNA) in the metastasis of gastric cancer. MethodsThe related works of lncRNAs in gastric cancer metastasis were searched from databases like Web of Knowledge and Pubmed, and analyzed after collected. ResultsThe emerging of lncRNAs has led to mounting interest in recent years.Increasing studies have elucidated that lncRNAs can regulate gene expression at the level of chromatin, transcription or posttranscription.Some aberrantly expressed lncRNAs have been revealed to modulate gastric cancer metastasis by regulating angiogenesis, cell to cell junction, and extracellar matrix. ConclusionAs essential regulators, lncRNAs can act as therapeutic targets, providing therapeutic bases to prevent gastric cancer metastasis.
ObjectiveTo explore the expression of MSI2 in gastric cancer and its association with clinical significance. MethodsThe expression level of MSI2 mRNA in gastric cancer tissues and para-carcinoma tissues was detected by Real-time PCR to explore its clinical significance. The expression level of MSI2 protein was detected by Western blotting. The prognosis of patients with the ratio of MSI2 mRNA expression level in gastric cancer tissues and adjacent normal tissues was more than 2 times and below 2 times were compared. ResultsThere was no significant difference between the expressions of MSI2 mRNA in cancer tissues and para-carcinoma tissues(P > 0.05). The expression level of MSI2 mRNA were associated with the invasion depth (P=0.017), TNM stage (P=0.028), differentiation (P=0.020), and size (P=0.030) of tumor, but no association with other clinical factors such as gender, age, and location were found. The overall survival of the patients with high expression of MSI2 mRNA was significantly shorter than that of the patients with low expression of MSI2 mRNA (χ2=4.221, P=0.040). ConclusionMSI2 expression is associated with the gastric cancer invasion, TNM stage and differentiation, and the patients with higher expression of MSI2 mRNA have poor prognosis, which makes it possible to be a potential therapeutic target.