Objective To summarize the clinical and research status in the surgical management of medullary thyroid carcinoma. Methods The related literatures on treatment of medullary thyroid carcinoma were collected and reviewed. Results A total thyroidectomy and dissection of the lymph nodes in the central compartment were effective treatments for patients with medullary thyroid carcinoma. The extent of lateral compartment lymph-node dissection did not reach an agreement. Prophylactic thyroidectomy was suggested for patients with a RET (rearranged during transfection) germline mutation. Palliative therapy was the main treatment of metastatic medullary thyroid carcinoma. Conclusions Surgery is the mainstay of treatment for medullary thyroid carcinoma. The combination of preoperative assessment, genetic testing, and appropriate surgical strategy may improve the prognosis of patients with medullary thyroid carcinoma.
ObjectiveTo summarize the clinical and genetic characteristics of parathyroid disease associated with CDC73 gene mutation.MethodsThe related literatures on CDC73 gene mutation and parathyroid diseases were collected and reviewed.ResultsCDC73 gene is a tumor suppressor gene which encodes parafibromin protein. CDC73 gene mutation may lead to the decrease or absence of expression of parafibromin protein. CDC73 gene mutation was directly associated with hyperthyroid-jaw tumor syndrome and 15% to 20% patients were associated with parathyroid carcinoma. Their first-degree relatives may also carry CDC73 gene mutation. Partial sporadic parathyroid carcinoma was associated with CDC73 mutation.ConclusionsCDC73 gene mutation is associated with various kinds of parathyroid diseases. Detection of CDC73 gene sequences and immunohistochemical analysis of parafibromin protein may be applied in the diagnosis and improve the prognosis of parathyroid diseases.
ObjectiveThrough dynamic monitoring of bacterial contamination of the bedside curtain in different time periods, the bacterial contamination of the bedside curtain in different time periods was analyzed.MethodsThe bedside curtain in the pediatric ward and obstetric ward were selected, between April and September 2019. All bedside curtains were sampled for bacterial contamination on the day after the replacement of it. During the continuous use of the bedside curtain for 6 months, the bacterial contamination was monitored at 1-, 2-, 3- and 6- months respectively.ResultsA total of 2 058 samples were monitored, including 1 041 in the pediatric ward and 1 017 in the obstetric ward. After continuous use for 2 months, there was clear pollution in the bedside curtain of pediatric ward, and the unqualified rate was 65.24%. Obstetrical ward were contaminated significantly after 1 month of use, and the unqualified rate was 51.96%.ConclusionsAs part of the sickbed unit, the bedside curtain is frequently touched by the hands of patients, family members and medical personnel during use. It is suggested that the septum should be replaced once a month in common wards and in time in case of pollution. For departments received patients with low immunity, the frequency of replacement should be increased to reduce environmental risk factors.