ObjectiveTo study the expression of Lumican in colorectal cancer tissues and investigate its role in the carcinogenesis and progression of colorectal cancer. MethodsLumican expression in 114 colorectal cancer and 43 normal tissues was detected by immunohistochemical SP method. ResultsLumican expression was negative in 43 normal colorectal tissues，while 79.82%（91/114） positive in cancer tissues, the difference of which was significant (Plt;0.05). The intensity of Lumican expression correlated conversely to the grade of differentiation for the colorectal cancer (Plt;0.05). So Lumican expression was statistically higher in Dukes A+B group than that in C+D group (Plt;0.05). There was no difference of Lumican expression in age and gender (Pgt;0.05). ConclusionsLumican didn’t express in normal colorectal tissues while expressed in cancer tissues, which suggests that Lumican may play a role in the carcinogenesis of colorectal cancer. The expression of Lumican is correlated with tumor differentiation grade and Dukes staging, which could be considered as an valuable index to biological features of colorectal cancer.