Objective To introduce the research progress on the technique of improving cell infiltration in electrospun scaffold. Methods The recent original articles about improving cell infiltration in electrospun scaffold were extensively reviewed and analyzed. Results The technique includes regulation of the electrospun parameters, modification of electrospun scaffold, and dynamic culture of scaffold-cells composite etc. The effect is limited and most of them need further optimization. Conclusion Cell infiltration in electrospun scaffold is of great significance in tissue engineering application. The relatively high compressed density and small pore size have become the bottleneck problem that prevents cell infiltration and tissue ingrowth into the scaffold. The combination of different techniques will be more effective to overcome this problem.