Objective To evaluate the cost effectiveness of human papillomavirus vaccine (HPV) for treating cervical cancer. Methods We constructed a Markov model to evaluate the cost-effectiveness of HPV versus Chinese healthy women aged 18 to 25 for treating Cervical Cancer. We calculated the clinical benefits and cost-effectiveness and judged the results based on willing to pay. Sensitivity analysis was made for parameters like cost, discounting rate and vaccine efficacy. Results HPV vaccination was a cost-effective option under the local willing to pay value with the incremental cost utility ratio 43 489 per QALY gained. It proved that vaccination was an economic and effective solution. Conclusion Given the results of Markov model, the cost effectiveness of HPV vaccination of Chinese women aged 18 to 25 is positive. Considering the data sources and model hypothesis, this report has some limitations. Further studies are warranted.
Objective To comprehensively analyze the research trends in the reported outcomes for lung cancer patients and related management, reveal research hotspots and trends, and provide references for future related research. Method We searched for relevant literature in the Web of Science core databases, PubMed, and Scopus databases from inception to December 31, 2023. CiteSpace bibliometric software was used to analyze the distribution of authors, countries and regions, research institution, keyword co-occurrence, keyword emergence, and draw keyword clusters and timeline analysis maps. Result A total of 479 qualified literatures were included, and the number of published papers showed an overall upward trend. The highest number of articles are issued in the United States. The journal with the highest number of articles is Journal of Pain and Symptom Management, and the journal with the highest citation frequency is Journal of Clinical Oncology. The results of keyword outburst analysis showed that hot topics were mainly focused on "prospective study", "physical activity", "exercise", "vomiting", "survival". ConclusionAlthough the research on lung cancer surgical treatment and the management of patients is developing rapidly, the application of management based on reported outcomes of lung cancer patients in lung cancer surgery is still in the exploratory stage and needs to be continuously improved in clinical research and clinical practice. The establishment of relevant assessment systems needs to be improved. In the future, more researchers need to focus on this area, strengthen multi-regional and multi-institutional collaborations, and accelerate research progress in the management of reported outcomes in lung cancer patients.