ObjectiveTo evaluate the safety and efficacy of single-layer seromuscular suture in ileocolonic anastomosis. MethodsFifty patients who needed ileocolonic anastomosis sugery were randomly divided into seromuscular anastomosis group (n=25) and two-layer anastomosis group (n=25). Intraoperative blood loss, perative time, postopreative complications, bowel function recovery time, and postoperative hospital stay time were recorded in each group. ResultsBlood loss, anastomotic leak, first passing gas time, first defecation time, and postoperative hospital stay time were (11.00±3.24) ml vs (10.28±2.99) ml (Pgt;0.05), 4.0% vs 8.0% (Pgt;0.05), (3.72±1.59) d vs (4.72±1.59) d (Pgt;0.05), (5.08±3.36) d vs (6.08±3.36) d (Pgt;0.05), and (8.47±2.32) d vs (10.26±2.61) d (Pgt;0.05), all the indexes above between the two groups had no significant difference. While a significant differnece in operative time was found between them 〔(11.74±2.02) min vs (16.44±2.06) min), Plt;0.01〕. ConclusionsSingle-layer seromuscular suture technique is safe and effective in ileocolonic anastomosis.