As an essential trace element for most organisms, iron is an important cofactor for various enzymes that performs key reactions. Siderophore has been considered as an important virulence factor. The cAMP receptor protein is an integral regulator, directly or indirectly involved in the regulation of siderophores-related genes in some prokaryotes and eukaryotes. This paper briefly introduces the cAMP receptor protein, and reviews the regulation of cAMP receptor protein on siderophores-related virulence genes of Klebsiella pneumoniae, Yersinia pestis, Vibrio vulnificus and Cryptococcus neoformans, in order to lay a theoretical foundation for clarifying the regulation mechanism of cAMP receptor protein on siderophores and provide a reference for pathogenic bacteria virulence control and clinical prevention.