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find Keyword "Stargardt病" 6 results
  • 不同病程Stargardt病的频域光相干断层扫描表现特征

    Release date:2016-09-02 05:42 Export PDF Favorites Scan
  • The clinical observation of the relationship between the macular pigment and the foveal cone function

    Objective To test the hypothesis that the macular pigment may be a marker of foveal cone function and consequently the structural integrity of foveal cones.Methods Sixteen patients (32 eyes) diagnosed to have Stargardt dystrophy and three patients with full thickness macular holes by clinical criteria were studied with a scanning laser ophthalmoscopy (SLO) comparing argon laser blue and infrared images for the presence or absence of macular pigment (MP) in the fovea. An C++ computer based program was used to evaluate the density of MP. Eyes were graded into three categories: those without foveal macular pigment, those with partial pigment and those with normal amounts of macular pigment. These categories were compared with visual acuity determined by the Snellen chart. Results Thirteen eyes with a visual acuity of 20/200 or worse had no macular pigment in the fovea. Eleven eyes with visual acuity of 20/40 or better had a normal amount of macular pigment in the fovea and 1 eye had partial macular pigment. Eleven eyes with partial macular pigment had intermediary acuity value.Conclusions Foveal macular pigment is closely related to foveal cone acuity and therefore may be a marker for the presence of foveal cones. Infrared light is a sensitive indicator of early macular diseases.(Chin J Ocul Fundus Dis,2003,19:201-268)

    Release date:2016-09-02 06:00 Export PDF Favorites Scan
  • The multi-focal electroretinogram of Stargardt′s disease

    Purpose To observe the features of multi-focal electroretinogram (mERG) in Stargardtprime;s disease, and evaluate the validity of mE RG on diagnosis of this disease. Methods mERG had been recorded in 7 cases (14 eyes) of Stargardtprime;s disease with VERIS 4.0,and the findings were compared with normal individuals. Results The mERG were remarkably abnormal in all cases of the disease, as the amplitudes of N1 and P1 waves were seriously decreased and the latencies were prolonged in all the 6 regions (Plt;0.01). The degrees of the amplitude changes of N1, P1 waves were not the same in those areas,and the most decreased part was in fovea. The responses of N1, P1waves from the fovea of patients were about 19 and 10 percent respectively of which in controls. As the eccentricity enlarged, these differences had a tendency of reduction. The mERG topography of this disease could be divided to two types, i.e. central decreased and diffuse decreased types. Conclusion There are remarkably abnormalities on mERG in Stargardtprime;s disease,and the most damaged location of macular function is in fovea. (Chin J Ocul Fundus Dis, 2001,17:271-273)

    Release date:2016-09-02 06:03 Export PDF Favorites Scan
  • Stargardt病的光学相干断层扫描图像特征

    Release date:2016-09-02 06:07 Export PDF Favorites Scan
  • 23例Stargardt病及黄色斑点状眼底病变的眼底荧光血管造影观察

    报告23例(46眼)Stargardt病及黄色斑点状眼底病变的眼底荧光血管造影所见.其中单纯黄斑变性16例,中心凹周围有斑点的黄斑变性5例,黄斑变性伴后极部弥散性黄色斑点1例,无黄斑变性的后极部弥散斑点1例.黄斑变性区表现为密集点状透见荧光,夹杂点状遮蔽荧光.大多数黄色斑点呈透见荧光,少数呈遮蔽荧光.4例显示脉络膜湮没征象.所有病例均未见荧光素渗漏.眼底荧光血管造影检查对于早期诊断具有十分重要的意义. (中华眼底病杂志,1993,9:93-94)

    Release date:2016-09-02 06:35 Export PDF Favorites Scan
  • The progress in treatment of type 1 of Stargardt disease

    Stargardt disease (STGD) is one of the most prevalent inherited macular dystrophy, and most often occurs in child or adolescence. Irreversible vision loss is observed in almost all cases. Type 1 (STGD1) is one of the most common type. It is an autosomal recessive condition, caused by mutations in the Abca4 gene. In recent years, encouraging progress has been made in the treatment of STGD1. C20-D3-retinyl acetate (ALK-001), fenretinide and ICR-14967 (A1120) as visual cycle modulators, StarGen as gene supplementation therapies, and the stem cell transplantation of human embryonic stem cell-derived retinal pigment epithelium cells are the most promising therapies. With the development of studies and clinical trials, the clinical application of various treatments of STGD1 are expected in the near feature, which are expected to save the vision of most patients.

    Release date:2021-07-21 02:14 Export PDF Favorites Scan
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