Shortly after Wenchuan earthquake, the administrative leaders of West China Hospital accurately defined the role of the hospital during the medical rescue work as the treatment center for the seriously wounded, the supporting center for the local hospitals/clinics of the disaster areas, and the logistic supporting center for medical teams from other provinces. Integrated leadership of management and with efficient multi-department coordination and cooperation were emphasized. The mode of the hospital was immediately transformed from the regular state into a double-track emergent state. Scientific allocation and dispatch of resources were ensured to meet the ever-changing demand from all levels of rescue work. Three stages were defined based on the conditions of the wounded delivered to the hospital, with different main focuses for each stage. Owing to the multi-disciplinary cooperation and concerted efforts of a large number of experts from other provinces or even other countries, effective and efficient medical rescue service has been offered to all the wounded. Up to June 2nd, 2?618 cases from the disaster area have been treated, of whom 1 751 admitted into the inpatient department, 1 135 seriously wounded, 127 admitted into the Intensive Care Unit, 1 239 underwent operations and 77 treated with hemodialysis, with an inpatient mortality lower than 0.7%. Moreover, even during such a period of time, the routine medical service has been offered as regular to patients other than the wounded in the disaster.