【摘要】 目的 总结胃间质瘤的诊断及治疗方法。 方法 回顾性分析2005年10月-2009年10月收治的15例胃间质瘤患者的临床资料。 结果 患者的主要临床表现为消化道出血、腹痛、腹胀、贫血等，全部手术切除。主要根据胃间质瘤大小和部位决定手术方式。有6例行胃大部切除，8例行胃楔形切除，1例经腹腔镜行胃楔形切除。 结论 胃间质瘤术前难以明确诊断，确诊有赖于术后病理和免疫组织化学检查，手术切除仍是治疗胃间质瘤的主要手段。【Abstract】 Objective To summarize the clinical experience in diagnosing and treating gastric stromal tumor. Methods The clinical data of 15 patients with gastric stromal tumor admitted from October 2005 to October 2009 was retrospectively reviewed. Results Among these patients, the clinical manifestations mainly included gastrointestinal bleeding, abdominal pain, abdominal flatulence, and anemia. All patients had undergone surgical resections. Mainly based on the size and location of the gastric stomal tumor, a specific operative procedure was decided for each patient. Of these patients, subtotal gastrectomy had been performed on six, gastric wedge resection on eight, and laparoscopic gastric wedge resection on one. Conclusion It is difficult to confirm the diagnosis of gastric stromal tumor before the operation. The diagnosis is usually confirmed by postoperative pathological and immunohistochemical examinations. Surgical resection remains to be the major therapeutic approach for gastric stromal tumor.