Medical institutions, the last defense line for the medical treatment of coronavirus disease 2019, are crucial to avoid cross-infection in hospitals. And how to reasonably arrange patient visits and achieve early detection, early reporting, early isolation, and early treatment of patients with coronavirus disease 2019 and suspected cases at the same time is an important proposition. After the outbreak of coronavirus disease 2019, West China Hospital of Sichuan University continued to supplement and improve implementation details based on the three-level pre-examination and triage of infectious diseases, and established a three-level pre-inspection and triage management mechanism more suitable for coronavirus disease 2019, and successfully applied it. This article introduces the process and results of this outpatient three-level pre-examination and triage management optimization practice, aiming to provide an experience reference for the outpatient three-level pre-examination and triage in medical institutions.