The spleen cells,from the Liwis rats on the 14th day after immunization with interphotoreceptor retinoid-binding protein(IRBP),were cultured alone or with IRBP for 48 hours.As high as 3times;10 7cells were intraperitoneously transfered to naive rats.The cells stimulated by IRBP in vitro were able to transfer both EAU,EAP and specific immune reactions,contrary to those cultured aloe which transfer neither EAU,EAP nor specific immune reactions.It is highly suggested that EAU is predominantly T cell-mediated and that cells incubation with IRBP prior to transfer is indispensable for induction of EAU in naive recipients. （Chin J Ocul Fundus Dis,1993,9:210-213）