Objective To evaluate the association between methylene tetrahydrofolate reductase (MTHFR) A1298C polymorphism and breast cancer in the Asain population. Methods PubMed, EMBASE, Web of science, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Periodical Database, Chinese Journal Full-Text Database, and Wanfang Database were searched to identify relevant articles that investigated the association of MTHFR A1298C polymorphism with breast cancer, the articles published time was from inception of database to March 2017. A meta-analysis was performed by using the Stata 12.0 software. Results A meta-analysis of 19 case-control studies was performed including 7 454 cases of breast cancer and 8 255 controls. The results of meta-analysis suggested that there was no significant association between MTHFR A1298C polymorphism and breast cancer for the Asain population under five genetic models 〔AA vs AC: OR=0.97, 95% CI was (0.91, 1.04), P=0.374; AC vs CC: OR=0.87, 95% CI was (0.75, 1.01）, P=0.060; AA vs CC: OR=0.87, 95% CI was (0.76, 1.01), P=0.061; AA+AC vs CC: OR=0.88, 95% CI was (0.76, 1.01), P=0.061; AC+CC vs AA: OR=0.99, 95% CI was (0.93, 1.06), P=0.737〕. Conclusion MTHFR A1298C polymorphism is not associated with breast cancer in the Asain population.
Objective To evaluate the association between fibroblast growth factor receptor 2 (FGFR2) rs2981582 polymorphism and the risk of breast cancer in Chinese population. Methods PubMed, Embase, Cochrane Library, Chinese Science and Technology Academic Journal, Chinese Biomedical Literature Database, Chinese Journal Full-Text Database, and Wanfang Database were searched to identify relevant articles that investigated the association of FGFR2 rs2981582 polymorphism with breast cancer risk from their inception to March 2018. A meta-analysis was performed by using the Stata 12.0 software. Results A total of 11 case-control studies were included in the present meta-analysis, including 5 921 breast cancer cases and 5 909 healthy controls. The pooled results indicated that, there was significant association between FGFR2 rs2981582 polymorphism and susceptibility of breast cancer in Chinese population under allele model ［C vs. T: OR=1.07, 95% CI was (1.01, 1.14), P=0.027］, heterozygote model ［CC vs. CT: OR=1.12, 95% CI was (1.01, 1.24), P=0.026］, homozygous model ［CC vs. TT: OR=1.19, 95% CI was (1.05, 1.34), P=0.005］, dominant model ［CC vs. CT+TT: OR=1.10, 95% CI was (1.00, 1.21), P=0.040］, and recessive model ［TT vs. CC+CT: OR=1.19, 95% CI was (1.10, 1.30), P<0.001］. Conclusion FGFR2 rs2981582 polymorphism was associated with the risk of breast cancer in Chinese population.