ObjectiveTo summarize the autophagy and its research progress in gastric cancer. MethodsIn combination with available literatures published in recent years involving the relationship between autophagy and gastric cancer, the characteristics of autophagy, molecular marker, control factors, and the significance and role in gastric cancer were reviewed. ResultsAutophagy not only promotes cell death, but also can prolong the survival of cancer cells during the tumor formation. Reagents (including traditional Chinese medicine) regulating autophagy have broad prospect of application in cancer therapy, but anti-tumor therapeutic effect based on the regulation of autophagy depends on the actual level of intracellular autophagy. ConclusionThe autophagy in the gastric cancer is still poorly understood, and to clarify the molecular mechanism of autophagy and kill cancer cells by reasonable regulation of autophagy still needs more further in-depth studies.
ObjectiveTo systematically review the model and mechanism, efficacy and its influencing factors of the promotion and application of appropriate health technology in China. MethodsSuch database as VIP, CNKI, CBM and WanFang Data were electronically searched to collect studies on the promotion and application of appropriate health technology in China published from the establishment dates to January 2013. According to the inclusion and exclusion criteria, two reviewers independently screened literature, extracted and cross-checked data, and assessed quality. Qualitative synthesis method was used to systematically summarize the included studies. ResultsA total of 73 studies were finally included. Targeted populations included primary medical staff and personnel who provided or developed appropriate health technologies, medical institutions and their managers, as well as patients who received service or treatment of appropriate health technology. The promotion of appropriate health technologies mainly contained five fields: Chinese medicine, biomedicine, family planning services, maternal and child health, and community health services. The government-leading model had been widely applied currently, besides, there were other four models: government-guidance, government-driven, market-leading and a third sector-leading models. Factors related to project funding, organization and management, technology holders, the supply and demand parties in technical services and technology itself might affect the application of appropriate health technology. Among all evaluation studies, the number of needs assessment was less, the contents of process evaluation were one-sided and the effect evaluation was mainly cross-sectional studies. ConclusionThis study shows that sustainable development of appropriate health technology promotion model need to fully consider market demand and people's needs, on the basis of using government-leading or introducing a third sector-leading model. Corresponding measures should be taken according to the influencing factors of promotion and application of appropriate health technology. It is necessary to conduct high quality evaluation studies in future and comprehensively evaluate the efficacy of the promotion and application of appropriate health technology.