ObjectiveTo summarize the research progress of the difference between high-flexion prosthesis and conventional prosthesis in total knee arthroplasty, so as to offer a reference for clinical choice of prosthesis. MethodsThe relevant literature on high-flexion prosthesis and conventional prosthesis in recent years was extensively reviewed and analyzed. ResultsThere are some controversies in range of motion and complications between high-flexion prosthesis and conventional prosthesis; while no obvious difference is found in knee function and satisfaction. ConclusionComprehensive evaluation should be considered when high-flexion prosthesis is selected; and the effectiveness needs further follow-up.