ObjectiveTo establish the model of nosocomial infection risk assessment, and evaluate its accuracy of prediction. MethodsThe model of nosocomial infection risk assessment was established by expert grading, and cross-section survey of nosocomial infection was used to evaluate the predictive effect from December 2013 to February 2014. ResultsThe infection risk score of the model had statistically significant influence on nosocomial infection [OR=1.35, 95%CI (1.26, 1.44), P<0.001]. The area under curve of the receiver operating characteristic curve was 0.754. The diagnostic test's sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 56.30%, 84.50%, 17.80%, 97.00% and 82.95% respectively, and the cutoff was 4. ConclusionThe model of nosocomial infection risk assessment has certain significance in the prediction of nosocomial infection, and can be regarded as a reference for establishing precaution system of nosocomial infection.