In the era of we-media, the external publicity work of hospitals has some problems, such as the content deviating from the needs of the audience, the internal and external publicity platforms being not separate, the synchronized operation of diversified platforms being difficult, and the stereotyped expression mode affecting the communication effect. Based on the practical experience and remarkable achievements of West China Hospital of Sichuan University in we-media construction, this paper puts forward that public hospitals should choose suitable content, channels, and ways of expression in order to give full play to we-media in their external publicity work.