Knee osteoarthritis (KOA) is the most common degenerative joint disease and one of the most disabling diseases in China, causing a huge economic burden to patients, families and society. Standardized KOA rehabilitation treatment is an important means to prevent and treat the disease and promote the development of high-quality medical services. This guideline was updated based on the 2016 and 2019 editions, and was initiated by the Chinese Medical Association Physical Medicine and Rehabilitation Branch and West China Hospital of Sichuan University. The guideline development was guided by domestic and international guideline development methods and principles, and 11 core clinical issues in two categories (rehabilitation assessment and treatment) were selected through clinical issue screening and deconstruction, and multiple rounds of Delphi questionnaire consultation. The International Classification of Functioning, Disability and Health (ICF) was used as the theoretical framework, and the Grading of Recommendations Assessment, Development and Evaluation (GR) was used based on the best available evidence. The International Classification of Functioning, Disability and Health (ICF) is a theoretical framework based on the best available evidence, and uses the Grading of Recommendations Assessment, Development and Evaluation (GRADE) method to grade the quality of evidence and recommendations, and reports them according to the Reporting Items for Practice Guidelines in Healthcare (RIGHT), taking into account patients' preferences and values and the needs of Chinese clinical practice, resulting in 11 key points and 28 recommendations to systematically standardize the rehabilitation of knee osteoarthritis.