This paper analyzes the health status and predicament of Mabian Yi Autonomous County before accepting assistance from West China Hospital of Sichuan University in 2016, and expounds the measures and achievements of West China Hospital of Sichuan University in building a “West China Hospital-Mabian model” of precision health poverty alleviation combining its own advantages and oriented by the needs of health poverty alleviation of Mabian Yi Autonomous County. The main contents of the model are putting an emphasis on the application and promotion of appropriate technologies, paying equal attention to technical and management help, combining “blood transfusion” and “hematopoiesis”, and taking the construction of a chimeric medical association as the carrier. The “West China Hospital-Mabian model” of precision health poverty alleviation provides a reference for continuously and systematically improving the technical level, service capacity and management level of grassroots hospitals in ethnic minority areas.