Objective To explore the knowledge distribution, knowledge clustering, and the trend in development of wound therapy, by revealing the same keywords with multiple statistical method and social network analysis. Methods We searched the CNKI under the term " wound” , " therapy” , and " wound therapy” in February 2016. After the core keywords had been identified by Bicomb and Endnote X6 software in each stage, the co-occurrence matrix was built. Transformation, dimensionality reduction and clustering of the co-occurrence matrix were finished by SPSS 22.0 software, leading the strategic plot to be built. The visualized network images were drawn using Ucinet 6.0 software. Results The visualized domain knowledge-mapping was successfully built, and it directly reflected the structure of knowledge-mapping of the discipline, as well as key clusters. Boost development had been identified in this research. The subject developed own core research areas and clusters, but there was still lack of fitting characteristics. The newly wound therapeutic techniques had limited correlation with other clusters, while provided limited contributions to forward this subject. However, enriched core keywords had been demonstrated, and formed clear domain parts of this subject. Conclusions The analysis demonstrates that wound therapy has developed well, and hot research points follow the direction of medication treatment. The network of wound therapeutic subject has become mature and completed within a short period. Comprehensive therapy and long term follow-up results according to evidence-based nursing have become the domain field. Moreover, the newly therapeutic techniques should be paid more attention to shift the development of this subject. And the interactive research within this subject and among other regions should be enhanced.