【Abstract】 Objective To compare the two different techniques determining tibial rotational al ignment in total kneearthroplasty(TKA) to enhance postoperative effect and reduce compl ications. Methods From May 2006 to April 2007, 60 patients(27 males, 33 females, aged 55-78 years ) received TKA and randomly divided into 2 groups(n =30): tibial rotational al ignmentin TKA was determined by medical 1/3 of tibial tubercle in Group A, by medial border of tibial tubercle at 0-9°varus inGroup B, by medical 1/3 of tibial tubercle at 20°or greater varus or by the mean l ine between medial border of tibial tubercle andmedical 1/3 of tibial tubercle at 10-19°varus. The angle of rotation of polyethylene cushion was calculated. Results The angleof rotation of polyethylene cushion in Group A was (8.4±3.8)° at 0-9°varus, (3.5±2.7)° at 10-19°varus and (0 ±2.4)° at 20°varusor over, respectively, and there was significant difference (P lt; 0.05). The angle of rotation of polyethylene cushion in Group Bwas (0 ±2.1)° at 0-9° varus, (0 ±2.0)° at 10-19°varus and (0 ±1.7)° at 20°varus or over, respectively, and there was no significantdifference (P gt; 0.05). The angle of rotation of polyethylene cushion averaged (5.6±2.8)°in Group A and (0±1.9)° in Group B,showing significant difference (P lt; 0.05). Conclusion The range of ideal tibial rotational al ignment in TKA was from medialborder of the tibial tubercle to medical 1/3 of the tibial tubercle, and is decided by the degree of varus deformities and valgus deformities.
Objective To review the advance in the researchand clinical application of the tibial rotational alignment technique in the total knee arthroplasty in China and abroad. Methods The recent literature concerned with the tibial rotational alignment technique in the totalknee arthroplasty was extensively reviewed and briefly summarized. Results According to the literature reviewed, the traditional tibial rotational references for the total knee arthroplasty were affected by many factors, so that the references were not accurate enough. There have been no unified references.ConclusionChoosing the range from the medial border of the tibial tubercle to the medial 1/3 of the tibial tubercle, decided by the degrees of the varus deformities and the valgus deformities, to determine the rotaional alignment of the tibial component will create an optimal tibiofemoral rotational alignment.
Objective To analyze the innovative ability of medical postgraduate students who have won national scholarships, and discuss the cultivation of innovative ability of clinical medicine postgraduate students and related factors. Methods A survey was based on the 2016 and 2017 postgraduate students majoring in clinical medicine at West China School of Medicine of Sichuan University. According to whether they had won a national scholarship, they were divided into a national scholarship group and a control group. The innovation ability and cognitive differences of the two groups of postgraduate students were compared, and related factors were explored. Results A total of 1 173 valid questionnaires were responsed, with a response rate of 80.23%. There was no statistically significant difference in gender and major between the two groups of postgraduate students (P>0.05). For master’s degree postgraduate students, the proportion of published papers in international medical journals (80.95% vs. 29.63%), published high impact factor (impact factor≥6) journal papers (7.84% vs. 6.16%), applied for research patents (12.70% vs. 3.51%) and innovation and entrepreneurship competition awards (20.63% vs. 3.93%) in the national scholarship group were higher than the control group, the differences were statistically significant (P<0.05). For doctor’s degree postgraduate students, the proportion of published papers in international medical journals (96.00% vs. 69.66%), published high impact factor journal papers (22.22% vs. 8.89%), applied for research patents (17.33% vs. 8.36%), and innovation and entrepreneurship competition awards (17.33% vs. 1.86%) in the national scholarship group were higher than the control group, the differences were statistically significant (P<0.05). Regarding the cognition of the composition of innovation ability, the differences between the national scholarship group and the control group were not statistically significant (P>0.05). Regardless of master’s degree or doctor’s degree, more than 40% of the postgraduate students in the national scholarship group and the control group believed that the most important factor in the personal influence of innovation ability was the knowledge factor, and more than 45% of the postgraduate students believed that the most important factors affecting the cultivation of innovative ability was their own factors or tutors’ factors. Conclusions The innovative ability of clinical medicine postgraduate students needs to be improved. The level of tutors’ scientific research ability, tutors’ guidance, high-quality scientific research team, and a good academic atmosphere play an important role in the cultivation of innovation ability. Optimizing the team of tutors, forming a scientific research steering group, building a high-level innovation platform, aiming at publishing high-level papers, strengthening domestic and foreign exchanges and cooperation, and motivating students to participate in innovation and entrepreneurship competitions are powerful measures to cultivate innovative medical talents.
ObjectiveTo review the role and mechanism of protein factors in bone remodeling, and provides theoretical basis for further elucidating the pathogenesis and clinical treatment of bone-related diseases. MethodsThe relevant research results at home and abroad in recent years were extensively consulted, analyzed, and summarized. ResultsBone remodeling is an important physiological process to maintain bone homeostasis. Protein, as an important stimulator in bone remodeling, regulates the balance between bone resorption and bone formation. ConclusionAt present, the research on the mechanism of protein in bone remodeling is insufficient. Therefore, it is necessary to further study the specific time, process, and interaction network of protein in bone remodeling, and to confirm its mechanism in bone remodeling, so as to reveal and treat the pathogenesis of bone-related diseases.