ObjectiveTo evaluate the role of cardiopulmonary bypass (CPB) technique in the treatment of the abdominal soft tissue tumor (ASTT). MethodClinical data of 9 patients with ASTT who underwent CPB-aided resection in zhongshan Hospital of Fudan University from April 2011 to December 2015 were analyzed retrospectively. ResultsAll patients were performed complete resection of tumor, without perioperative death. Six patients received complete CPB technique and other 3 patients received partial CPB technique. In establishment of CPB, patterns of arterial perfusion included the ascending aorta (n=6) and femoral artery (n=3); patterns of venous drainage included the inferior vena cava (n=2), superior vena cava (n=6), femoral vein (n=2), and jugular vein (n=3). Among of them, 7 patients were diagnosed as intravenous leiomyomatosis, 1 patient was diagnosed as small round cell malignant tumor, and another 1 patient was diagnosed as leiomyosarcoma. Two patients occurred postoperative complications, 1 patient was duodenal fistula, with conservative treatment to heal; another 1 patient was inferior vena cava thrombosis, with treatment of placement of the inferior vena cava filter. Nine patients received follow-up, and follow-up time was 1-57 months (the median time was 4-month), and the survival rate was 100%, no one suffered from recurrence. ConclusionsFor some patients with complicated ASTT, CPB technique can provide chance to completely resect the tumors.