ObjectiveTo summary the relationship between CD147 and the occurrence and development of hepatocellular carcinoma, and its roles in clinical diagnosis and treatment. MethodReferring to the related literatures in recent years at home and abroad, the concept of CD147, and its relationship with the occurrence, development, invasion, and metastasis of hepatocellular carcinoma were reviewed. ResultsCD147 plays a key role in the development, progress, invasion, and metastasis of hepatocellular carcinoma. CD147 can be used as a long-term outcome predictor for hepatocellular carcinoma patients and also began to show its in hepatocellular carcinoma target therapy. ConclusionThere are numerous studies about the relationship between CD147 and hepatocellular carcinoma, but still exists some problems to be further studied.
ObjectiveTo summary the detection methods of circulating tumor cells (CTCs) in pancreatic cancer patients and its clinical application. MethodsRelated domestic and foreign literatures were reviewed. ResultsPancreatic cancer is one of the common malignant tumors in the world. The early diagnosis rate is low, the incidence of local invasion and metastasis is high, and the prognosis is very poor. The CTCs is one of the important causes of postoperative recurrence and metastasis, its detection methods based on immunocytochemistry (ICC) and reverse transcription polymerase chain reaction (RT-PCR). ConclusionsDetection of CTCs, regarding as a "real-time liquid biopsy", it has a high application value in the early diagnosis, treatment, prognosis and effect evaluation of pancreatic cancer, and it has become research frontier and focus.