ObjectiveTo evaluate the efficacy and safety of prostat in combination with antibiotic on the treatment of chronic proatatitis. MethodsWe searched the literatures which were randomized controlled trials (RCT) on the treatment of combination of prostat and antibiotic for chronic prostatitis published between January 2003 and August 2013 in the Databases including CNKI, Wanfang database, VIP, CBM, PubMed, according to the demand of Cochrane Colloboration, combining computer retrieval with manual retrieval. The quality of literature was assessed by using Jadad scale and extract data from literature. Meta-analyses were performed by using the RevMan 5.1 Software. ResultsA total of 12 clinical RCT, involving 3 947 patients were identified. One study was double-blind and three studies were single-blind. Only one study had a Jadad scale score of 3, belonging to high quality document; the rest had a score of 2 or 1, and all were low quality documents. The results of the Meta-analysis showed that compared with the control groups, the treatment of combination of prostat with gatifloxacin on chronic prostatitis had a significant difference in total effective rate[OR=3.98, 95%CI (2.67, 5.94), P<0.000 01], NIH-CPSI score[WMD=-6.45, 95%CI(-7.55, -5.34), P<0.000 01]; the treatment of combination of prostat with Levofloxacin on chronic prostatitis had a significant difference in total effective rate[OR=1.71, 95%CI (1.43, 2.05), P<0.000 01], NIH-CPSI score[WMD=-2.85, 95%CI(-3.39, -2.31), P<0.000 01]. ConclusionThe treatment of combination of prostat with antibiotic was superior to the treatment of prostat or antibiotics on chronic prostatitis. It is an effective therapeutic schedule. But the safety of the treatment of combination of prostat and antibiotic on chronic prostatitis needs further evaluation.