【摘要】 目的 观察激光、白介素-2、膦甲酸钠联合治疗尖锐湿疣的疗效。 方法 2007年1月-2009年4月将收治的412例尖锐湿疣患者随机分为:A组140例采用激光治疗，B组138例采用激光、白介素-2治疗，C组134例在B组基础上联合膦甲酸钠治疗。 结果 C组的总有效率为97.7%，明显高于A、B两组，组间比较，有统计学意义（Plt;0.05）；且C组的复发率最低，为4.6%。 结论 激光、白介素-2、膦甲酸钠联合治疗尖锐湿疣获得较佳疗效，且复发率低，值得临床关注。【Abstract】 Objective To observe the effect of combinging laser, interleukin (IL-2) and foscarnet sodium on condyloma acuminatum. Methods From January 2007 to April 2009, 412 patients with condyloma acuminatum were randomly divided into three groups, 140 patients with single laser were in group A, 138 patients with laser and IL-2 were in group B, 134 patients with laser, IL-2 and foscarnet sodium were in group C. Results The total effective rate was 97.7% in group C, which was significantly higher than those in group A and B (Plt;0.05); and the recurrence rate was the lowest in group C (4.6%). Conclusion The combination of laser, IL-2 and foscarnet sodium has better efficacy and lower recurrent rate on condyloma acuminatum, it is worthy of spreading to application.