【摘要】 目的 了解原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后的眼压及眼脉动幅度变化特征。 方法 选取2009年1－12月确诊为原发性开角型青光眼患者19例32只眼。给予2%盐酸卡替洛尔滴眼液点眼1周，2次/d。用动态轮廓眼压计测量患者用药前后的眼压、眼脉动幅度，同时测量患者的血压及心率。比较用药前后眼压及眼脉动幅度的变化，并用SPSS 14.0统计学软件对用药前后的眼压及眼脉动幅度数据进行配对t检验及Pearson相关性分析。 结果 患者用药前后眼压分别为（22.76±4.29）、（17.79±2.93） mm Hg（1 mm Hg=0.133 kPa），眼脉动幅度分别为（3.47±1.00）、（2.63±0.86） mm Hg。患者的眼压及眼脉动幅度用药后较用药前明显降低，差异有统计学意义（Plt;0.01），用药前后的眼压与眼脉动幅度之间存在正相关关系（r=0.444， 0.364；P=0.011， P=0.040）。眼压及眼脉动幅度与患者的血压及心率均无相关性。 结论 原发性开角型青光眼患者用2%盐酸卡替洛尔滴眼液后眼压及眼脉动幅度均有显著降低，眼压与眼脉动幅度有正相关性。眼压及眼脉动幅度与血压及心率无相关关系。【Abstract】 Objective To investigate the variations of intraocular pressure (IOP) and ocular pulse amplitude (OPA) in patients with primary open-angle glaucoma after 2% carteolol hydrochloride was applied. Methods Thirty-two eyes of 19 patients with primary open-angle glaucoma diagnosed between January and December 2009 were chosen to be the study subjects. The patients received 2% cartelol hydrochloride eye drops twice a day for one week. IOP and OPA before and after using cartelol were measured by dynamic contour tonometry (DCT). Blood pressure and heart rate were detected at the same time. The variations of IOP and OPA were analyzed by SPSS 14.0. t test and Pearson correlation analysis were applied. Results The mean IOP and OPA before and after using cartelol were respectively (22.76±4.29) mm Hg (1 mm Hg=0.133 kPa) vs. (17.79±2.93) mm Hg, and (3.47±1.00) mm Hg vs. (2.63±0.86) mm Hg. Both of them decreased significantly after the use of cartelol (P＜0.01). OPA was obviously correlated with IOP both before and after using cartelol (r=0.444, 0.364; P=0.011, 0.040). OPA and IOP had no correlation with blood pressure and heart rate. Conclusions OPA and IOP decreases signifficantly after the use of 2% carteolol hydrochloride. OPA is signifficantly correlated with IOP. OPA and IOP have no correlation with blood pressure and heart rate.
ObjectiveTo evaluate the combination efficacy with Qingfei Yihuo capsule and routine antibiotics as well as mucopolytic agents in the treatment of bronchiectasis acute exacerbation.MethodsThis was a prospective, multi-center, randomized controlled clinical study. The efficacy of Qingfei Yihuo capsule combine with routine antibiotics and mucopolytic agents in the treatment of bronchiectasis acute exacerbation was compared according to the symptom control as well as exacerbation duration. Through randomization, patients received Qingfei Yihuo capsule or placebo combine with routine antibiotics and mucopolytic agents treatment for 10 days. Symptom score of cough, sputum, short of breath pre- and post-treatment as well as the symptom score in daily card were compared between the two groups. The spirometry and St. George respiratory questionnaire (SGRQ) before and after treatment were compared.ResultsThis study was conducted from June 2017 to August 2018. One hundred and ninety patients from 7 centers in 6 hospitals with bronchiectasis acute exacerbation were enrolled in the study. There was statistically improvement of symptom score (including the 9th and 10th treatment days) according to the daily card recording in Qingfei Yihuo capsule group compared to the placebo group, but no statistically significant difference was found in spirometry results or SGRQ.ConclusionQingfei Yihuo capsule has assistant effect on improving respiratory symptoms of bronchiectasis exacerbation.
Objective To investigate short-term effectiveness and clinical application advantages of orthopedic robot-assisted resection for osteoid osteoma compared with traditional open surgery. Methods A retrospective analysis was conducted on clinical data of 48 osteoid osteoma patients who met the selection criteria between July 2022 and April 2023. Among them, 23 patients underwent orthopedic robot-assisted resection (robot-assisted surgery group), and 25 patients received traditional open surgery (traditional surgery group). There was no significant difference (P>0.05) in gender, age, disease duration, lesion location and size, and preoperative visual analogue scale (VAS) score, and musculoskeletal tumor society (MSTS) score between the two groups. The surgical time, intraoperative blood loss, intraoperative lesion localization time, initial localization success rate, infection, and recurrence were recorded and compared. VAS scores before surgery and at 24 hours, 1, 3, 6, and 9 months after surgery and MSTS score before surgery and at 3 months after surgery were assessed. Results All patients completed the surgery successfully, with no significant difference in surgical time between the two groups (P>0.05). Compared to the traditional surgery group, the robot-assisted surgery group had less intraoperative blood loss, shorter lesion localization time, and shorter hospitalization time, with significant differences (P<0.05). The initial localization success rate was higher in the robot-assisted surgery group than in the traditional surgery group, but the difference between the two groups was not significant (P>0.05). All patients in both groups were followed up, with the follow-up time of 3-12 months in the robot-assisted surgery group (median, 6 months) and 3-14 months in the traditional surgery group (median, 6 months). The postoperative MSTS scores of both groups improved significantly when compared to those before surgery (P<0.05), but there was no significant difference in the changes in MSTS scores between the two groups (P>0.05). The postoperative VAS scores of both groups showed a gradually decreasing trend over time (P<0.05), but there was no significant difference between the two groups after surgery (P>0.05). During follow-up, except for 1 case of postoperative infection in the traditional surgery group, there was no infections or recurrences in other cases. There was no significant difference in the incidence of postoperative infection between the two groups (P>0.05). Conclusion Orthopedic robot-assisted osteoid osteoma resection achieves similar short-term effectiveness when compared to traditional open surgery, with shorter lesion localization time.