【摘要】 目的 比较利多卡因不同剂量预处理对罗库溴铵注射痛的影响。 方法 120例行全身麻醉择期手术的患者按照完全随机的方法分为利多卡因10 mg 3 mL预处理组（A组），利多卡因25 mg 3 mL预处理组（B组），利多卡因50 mg 3 mL预处理组（C组），生理盐水3 mL预处理组（D组）。观察不同剂量的利多卡因预处理对罗库溴铵注射痛的影响。 结果 A、B、C和D组注射罗库溴铵的疼痛发生率分别为53%、27%、3%和90%。与生理盐水预处理组相比，利多卡因预处理组能明显减轻罗库溴铵引起的注射痛（Plt;0.01）；剂量越大，效果越明显。 结论 利多卡因10、25、50 mg预处理均能显著降低罗库溴铵注射时引起的疼痛，以50 mg利多卡因更为有效。【Abstract】 Objective To compare the effects of different doses of lidocaine pretreatment on the pain from injection with rocuronium. Methods One hundred and twenty patients of general anesthesia had undergone elective surgery, were randomly divided into lidocaine 10 mg 3 mL pretreated group (group A), lidocaine 25 mg 3 mL pretreated group (group B), lidocaine 50 mg 3 mL pretreated group (group C) and saline 3 mL pretreated group (group D). The effects of different doses of lidocaine pretreatment on injection pain of rocuronium were observed. Results The pain incidence from injection with rocuronium in A, B, C, D groups were 53%, 27%, 3% and 90% respectively. The higher dose of lidocaine, the more obvious effect. Conclusion Lidocaine pretreatment with 10, 25, 50 mg can reduce the severity of pain from injection with rocuronium, and lidocaine 50 mg is the most effective.