This paper aims to investigate the value of diffusiion weighted imaging (DWI) and different apparent diffusion coefficient (ADC) methods to predict the curative effects of neoadjuvant chempotherapy (NAC) for breast cancer. From March 2010 to December 2012, seventy-one patients were pathologically confirmed invasive breast cancer by needle puncture biopsy received before surgery, and underwent magnetic resonance before and after NAC, the ADC were measured by mean ADC method and lower ADC method. The pathologic response after NAC was divided to major histological response (MHR) group and non-major histological response (NMHR) group according to Miller & Payne system. Results displayed that ADC values obtained before NAC, at the end of the second cycle of NAC, and after whole course of treatment, had good correlations between mean and lower ADC methods (the Pearson's correlation=0.699, 0.749 and 0.895, respectively). Significant difference in ADC obtained both with mean and lower ADC methods could be found between MHR and NMHR groups after the second cycle of NAC (P<0.05). After the second cycle of NAC, significant difference in the change rate of ADC could be found between MHR and NMHR groups by using lower ADC method (P<0.05), but not be found by using mean ADC method (P＞0.05). In conclusion, DWI could monitor the pathologic changes of breast cancer after NAC, and the lower ADC method might be used to evaluate the curative effect of NAC with the change rate of ADC.
Objective To detect the features of breast carcinoma with nipple discharge using selective galactography and evaluate the value of this method. Methods The galactography findings of 39 cases of pathology proved breast carcinoma with nipple discharge were analyzed retrospectively. Results Among the 39 cases, the pathology diagnosis included 7 cases of intraductal papillary carcinoma, 13 cases of ductal carcinoma in situ, and 19 cases of invasive ductal carcinoma. The galactographic features included: duct filling defect (24 cases, 61.5%), ductal obstruction (15 cases, 38.5%), rigidity and disorder (31 cases, 79.5%), wormy erosion sign (18 cases, 46.2%), pond lake sign (4 cases, 10.3%), ductal interruption (17 cases, 43.6%), ductal stenosis (24 casesm, 61.5%), ductal dilatation (22 cases, 56.4%). Among all of the cases, the accuracy rate of mammography and galactography was 64.1% (25/39) and 87.2% (34/39), respectively (P＜0.05). Among the 13 cases of ductal carcinoma in situ, the accuracy rate of mammography and galactography was 61.5% (8/13) and 100% (13/13), respectively (P＜0.05). Conclusion Selective galactography could improve the detection rate of breast carcinoma, and has great value in the early diagnosis of ductal carcinoma in situ.