In order to meet the rapid development of in-vitro diagnostic reagent (IVD) market and the development needs of laboratory medicine, and ensure efficient management and cost control in IVD purchasing, it is necessary to build the purchasing management standard, improve the purchasing quality of IVD, reduce the overall hospital costs, and ensure the accuracy and reliability of clinical test results. Through three aspects: the preparation before business negotiation, business negotiation, and execution after business negotiation, this article clarifies the self-bidding procurement process of IVD, and emphasizes the importance of knowledge in IVD procurement management, so as to provide references and suggestions for novice buyers to get familiar with the business quickly and improve their negotiation ability.