Objective To systematically review the impacts of general anesthesia using sevoflurane versus propofol on the incidence of emergence agitation in pediatric patients. Methods Such databases as PubMed, EMbase, Web of Science, The Cochrane Library (Issue 4, 2012), CNKI, CBM, WanFang Data and VIP were electronically searched from inception to December 2012, for comprehensively collecting randomized controlled trials (RCTs) on the impacts of general anesthesia using sevoflurane versus propofol on the incidence of emergence agitation in pediatric patients. References of included studies were also retrieved. Two reviewers independently screened literature according to the inclusion and exclusion criteria, extracted data, and assessed the methodological quality of included studies. Then, meta-analysis was performed using RevMan 5.1 software. Results A total of 9 RCTs involving 692 children were included, of which, six were pooled in the meta-analysis. The results of meta-analysis showed that: a) after anesthesia induction using sevoflurane, intravenous propofol maintenance was associated with a lower incidence of emergence agitation compared with sevoflurane maintenance (RR=0.57, 95%CI 0.39 to 0.84, P=0.004); and b) patients anesthetized with total intravenous propofol had a lower incidence of emergence agitation compared with total inhalation of sevoflurane (RR=0.16, 95%CI 0.06 to 0.39, Plt;0.000 1). Conclusion The incidence of emergence agitation after general anesthesia using sevoflurane is higher than that using propofol. Due to the limited quantity and quality, the application of sevoflurane should be chosen based on full consideration into patients’ conditions in clinic.
Objective To evaluate the histocompatibil ity of porous hydroxyapatite (HAP) coating NiTi shape memory alloy and to provide a theoretical basis for its cl inical appl ication in bone defect repair. Methods Twenty-four Chinchilla rabbits weighing 2.0-2.5 kg were randomized into experimental group and control group (n=12). HAP coating NiTi shape memory alloy was implanted into the distal part of left femur of 12 rabbits in the experimental group, while holes without alloy implantation were performed on the control group. At 7, 14, 28 and 56 days after implantation, the animals werekilled (3 rabbits in each group at a time). Gross observation, histology observation, BMP-2 immunohistochemistry observation and image grey scale analysis were performed. And the histology observation was evaluated by GB/T16886.6-1997 in terms of inflammation, capsule wall of fibrous tissue, materials degradation and the response of peripheral tissue. Results All of the animals survived until being killed. The implants reached a peak embedded in bone tissue wholly, without loosening and bone absorption. The inflammatory cell infiltration and fibrous hyperplasia were at 7 days after implantation, with the formation of cyst wall of fibrous tissue and the implant wrapped by the cyst wall. The response of connective tissue proliferation was still obvious in partial samples of experimental group at 56 days after implantation, which was wrose than the control group but consistent with the in vivo implantation standard of GB/T16886.6-1997. Immunohistochemistry observation displayed the endogenous BMP-2 were in the cytoplasm of MSCs and osteoblast. The result of image analysis showed the expression of BMP-2 were staged in line with the repair of bone defect, two groups witnessed the peak expression of the BMP-2 at 14 days after implantation. There wereno significant differences among different time points in the staining gray scale of BMP-2 (P gt; 0.05). Conclusion HAP coating NiTi shape memory alloy, as a biomedical material, has excellent histocompatibility with bone.
Due to the coronavirus disease 2019 pandemic, the traditional outpatient and medical center pulmonary rehabilitation models for chronic obstructive pulmonary disease have been limited, while pulmonary rehabilitation technology has always been the focus of clinical and scientific research in rehabilitation. This article reviews the application status of remote pulmonary rehabilitation for chronic obstructive pulmonary disease under the coronavirus disease 2019 epidemic in recent years. From the selection and method of remote pulmonary rehabilitation equipment before the epidemic, to the development of rehabilitation forms and equipment innovation after the epidemic, the current status and problems of remote pulmonary rehabilitation are clarified. Establishing a remote pulmonary rehabilitation model in line with China’s national conditions is the direction and goal of future development.
Polyurethane materials have good biocompatibility, blood compatibility, mechanical properties, fatigue resistance and processability, and have always been highly valued as medical materials. Polyurethane fibers prepared by electrostatic spinning technology can better mimic the structure of natural extracellular matrices (ECMs), and seed cells can adhere and proliferate better to meet the requirements of tissue repair and reconstruction. The purpose of this review is to present the research progress of electrostatically spun polyurethane fibers in bone tissue engineering, skin tissue engineering, neural tissue engineering, vascular tissue engineering and cardiac tissue engineering, so that researchers can understand the practical applications of electrostatically spun polyurethane fibers in tissue engineering and regenerative medicine.