【摘要】 目的 观察光子嫩肤合并左旋维生素C导入治疗面部黄褐斑的临床疗效。 方法 2008年3月-2009年5月，105例黄褐斑患者随机分为两组，治疗组53例，用光子嫩肤治疗2个疗程后用左旋维生素C导入，1次/周，持续2个月；对照组52例，单纯使用光子嫩肤治疗后进行防晒、护肤治疗2个月。 结果 治疗组有40例黄褐斑消失，13例色斑明显减淡；对照组有12例黄褐斑消失，26例色斑明显减淡，11例色斑减淡，3例无效。两组疗效比较，差异有统计学意义（Plt;0.05）。 结论 光子嫩肤合并左旋维生素C导入治疗面部黄褐斑安全、方便、疗效好，患者易于接受。【Abstract】 Objective To observe the clinical efficacy of the treatment of facial melasma by intense pulsed light (IPL) photorejuvenation combined with vitamin C. Methods From March 2008 to May 2009, 105 patients with facial melasma were randomly divided into two groups. In the treatment group, there were 53 patients who were treated with vitamin C after IPL photorejuvenation once a week for two months. For the 52 patients in the control group, sunscreen and skin care treatment were carried out after IPL treatment for two months. Results In the treatment group, 40 patients’ melasma disappeared and 13 patients’ melasma dodged obviously. In the control group, 12 patients’ melasma disappeared and pigmentation existed more or less in 40 patients. Conclusion Treatment for facial melasma by IPL photorejuvenation combined with vitamin C is safe, convenient, and have good effect, which can be easily accepted by the patients.