【Abstract】 Objective To investigate the method and effectiveness of expanded delto-pectoral and abdominalperforator flaps in repairing large defects of the face and upper limb after scar excision. Methods Between August 2000 and February 2011, 25 patients with large scars on face and upper l imb were treated. There were 14 males and 11 females with an average ageof 27 years (range, 7-36 years). Scars causes were burn and scald in 25 cases with a disease duration of 6 months to 7 years (mean, 4.5 years). The hypertrophic scars located at face in 15 cases, and at upper limb and hand in 10 cases. The soft tissue expanders (300-500 mL in volume) were implanted in the delto-pectoral zone and abdominal region in one-stage operation. In two-stage operation, after scars were resected, defects (9 cm × 7 cm to 17 cm × 8 cm) were repaired with the delto-pectoralperforator flaps (17 cm × 7 cm to 20 cm × 8 cm) in 15 facial scar cases and with the deep inferior epigastric artery perforator flaps (10 cm × 9 cm to 25 cm × 14 cm) in 10 upper limb and hand scar cases. The donor sites were sutured directly. Results Partial necrosis of the flaps occurred in 2 cases after operation, then the flap survived after expectant treatment. The other flaps and skin grafts survived successfully, and the incisions healed by first intention. Ten patients were followed up 6 months to 4 years. Theappearance, texture, and color of the flaps were similar to those at the donor site. Conclusion It is an effective method to use the delto-pectoral perforator flap and the deep inferior epigastric artery perforator flap for repairing soft tissue defects of the face and upper limb after scar excision.
Tuberculosis risk prediction and drug intervention for latent tuberculosis infection (LTBI) patients plays an important role in achieving the goal of eliminating tuberculosis. At present, the diagnostic methods of LTBI still have some defects and cannot predict the risk of LTBI progression to active tuberculosis. In this paper, studies of LTBI advancing into tuberculosis in genomics, transcriptomics, proteomics and metabonomics have been comprehensively summarized, and the further development of markers for risk prediction is prospected.
Objective To compare the long-term efficacy of carotid artery stenting (CAS) and carotid endarterectomy (CEA) in the treatment of carotid artery stenosis by meta-analysis. Methods PubMed, Embase, Medline, Cochrane Library, China National Knowledge Infrastructure, Wanfang database, Chongqing VIP database, and SinoMed were searched, for randomized controlled trials comparing the efficacy of CAS and CEA in the treatment of carotid artery stenosis published before September 2nd, 2021. Stata 15.1 software was used to analyze the long-term outcome data, including any stroke, ipsilateral stroke, fatal or disabling stroke, any death, combined endpoint of stroke or death, and carotid artery restenosis. Results A total of 20 English articles from 9 studies were included, involving 8551 patients (4658 in the CAS group and 3893 in the CEA group). The medians of the follow-up time of these studies were 2-10 years. The meta-analysis showed that the risks of any stroke [hazard ratio (HR)=1.33, 95% confidence interval (CI) (1.16, 1.52), P<0.0001], ipsilateral stroke [HR=1.26, 95%CI (1.02, 1.55), P=0.034], and the combined endpoint of stroke or death [HR=1.17, 95%CI (1.02, 1.33), P=0.021] in the CAS group were significantly higher than those in the CEA group, while the risks of fatal or disabling stroke [HR=1.19, 95%CI (0.94, 1.51), P=0.152], any death [HR=1.06, 95%CI (0.95, 1.18), P=0.302], and restenosis [HR=1.20, 95%CI (0.96, 1.49), P=0.111] were not significantly different between the CAS group and the CEA group. Conclusions CAS and CEA have similar risks in terms of long-term fatal or disabling stroke, death, and carotid artery restenosis, but the long-term risks of any stroke, ipsilateral stroke and combined endpoint of death or stroke of CAS are higher than those of CEA. CEA is still the preferred non-drug method for carotid artery stenosis.
ObjectiveTo investigate the feasibility of magnamosis rings designed based on magnetic compression technique in esophageal anastomosis reconstruction.MethodsAccording to the anatomical characteristics of esophagus in SD rats, the esophageal magnamosis rings were designed. SD rats were used as animal models (n=10, 5 males and 5 females) to complete the magnetic anastomosis reconstruction of the cervical esophagus using magnamosis rings, and the operation time, animal survival, postoperative complications, magnetic rings excretion time were recorded. Two weeks after operation, the rats were killed, and the esophageal anastomotic specimens were obtained. The blasting pressure of the anastomotic site was measured and the formation of the anastomotic site was observed with naked eyes.ResultsEsophageal magnamosis was successfully performed in 10 SD rats, and the median operation time was 11 (8-13) min. All rats survived without anastomotic leakage, anastomotic stenosis, or magnetic rings incarceration. The magnetic rings were discharged after 8 (5-10) days and the burst pressure was higher than 300 mm Hg. Visual observation showed that the anastomotic muscle healed well and the mucosa was smooth.ConclusionThe magnetic compression technique can be used for anastomosis reconstruction of esophagus, which has the advantages of simple operation and reliable anastomosis effect, and has clinical application prospect.