Objective To visually present the related research progress, hot spots, frontiers, and trends of Guizhi Shaoyao Zhimu decoction (GSZD) in China in the recent 11 years, aiming at better guiding related clinical research. Methods The published GSZD-related articles were searched in China National Knowledge Infrastructure, Wanfang Database, Wanfang Medical Network, and VIP Chinese Journals Service Platform, and the time limit was from January 1st, 2012 to December 8th, 2022. After screening, CiteSpace 6.1.R3 software was used to visually analyze the included documents. Results A total of 1791 articles were retrieved, and 595 articles were included after screening. The number of papers published in the year showed a fluctuating upward trend. The included articles were from 179 journals and 21 universities and research institutes, among which 12 institutions (including 11 journals) published more than or equal to 10 articles, the cumulative number of articles published by these 12 institutions accounted for 27.23% of the total number of articles published, and Journal of Rheumatology and Arthritis published the most papers (22 articles). The main author teams in this field were Gao Yongxiang, Liu Zhenli, and Fang Shubiao. Through keyword analysis, 8 co-occurrence keywords, 10 clustering modules, and 25 emergent keywords were formed. Conclusions In the future, GSZD-related research will continue to grow, and it has great development potential. Research teams should closely cooperate strengthen exchanges, and develop their potential under the guidance of the idea of integrating traditional Chinese and Western medicine, to help it develop better and better serve clinical applications.