Endometriosis (EM) is a common benign gynecological disease with complex pathogenesis and lack of unified understanding. In recent years, the theory of stem/progenitor cells has gradually been recognized by scholars. The presence of stem/progenitor cells in the endometrium and researchers’ understanding of stem/progenitor cell specific markers has been further developed, which is of great significance for sorting stem/progenitor cells and further elucidating their roles in the pathogenesis of EM. At present, more endometrial stem cell signaling pathways have been studied including Wnt, Hedgehog, Notch, phosphatidylinositol-3-kinase/protein kinase B, Smad/connective tissue growth factor, CXCL12/CXCR4, etc. These signaling pathways can regulate stem cell involvement in the pathogenesis of EM. Exploring how signaling pathways to regulate stem cell involvement in the pathogenesis of EM can help elucidate the specific pathogenesis of EM and provide new directions for its treatment. This paper will summarize them.
ObjectiveTo summarize ways and advantages of applying polydioxanone (PDO) material in surgical field.MethodThe literatures related to the application of PDO materials in the surgery were reviewed and summarized.ResultsThe current researches showed that the PDO material could be used as the stent, carrier, suture, vena cava filters, and hemostatic clips in the surgical field, and its effect was superior to the traditional material products.ConclusionsGood biological properties of PDO materials make them suitable for use in surgical field. Despite it has outstanding advantages, its drawbacks cannot be ignored. PDO materials are currently limited in application and further research is needed to assess its true clinical feasibility, safety, and efficacy.