ObjectiveTo detect the expressions of NKD1 and APC in breast carcinoma tissues and to explore the clinical significance of their existence and their correlation. MethodsThe study selected 75 patients with breast carcinoma as the observation group, and their corresponding normal breast tissues from the breast carcinoma tissues more than 5 cm as the control group. The expressions of two proteins were detected by immunohistochemistry. Their relationship with the pathological characteristics of breast carcinoma and the correlation of the two proteins were analyzed. ResultsThe positive expression rates of NKD1 and APC in normal breast tissues were significantl higher than those in breast carcinoma tissues (82.67% vs. 36.00%, 89.33% vs. 45.33%, P < 0.05). The expression of NKD1 was not correlated with the age of patients with breast carcinoma (P > 0.05), while correlated with the degree of differentiation, TNM stage, lymph node metastasis, and remote organ metastasis of breast carcinoma (P < 0.05). The expression of APC was not correlated with the age of patients with breast carcinoma, the degree of differentiation and lymph node metastasis of breast carcinoma (P > 0.05), while correlated with the TNM stage and remote organ metastasis of breast carcinoma (P < 0.05). The expressions of NKD1 and APC in breast carcinoma was positively correlated (r=0.609, P < 0.05). ConclusionNKD1 and APC may be involved in the development and remote organ metastasis of breast carcinoma, and the two proteins may have a synergistic role in breast carcinoma.
ObjectiveTo explore the effectiveness and method of Ilizarov technology for the treatment of infected forearm nonunion. MethodsBetween January 2004 and March 2014, 19 patients with infected forearm nonunion were treated, including 12 males and 7 females with a mean age of 37.4 years (range, 18-62 years). The injury causes included traffic accident in 11 patients, falling from height in 4 patients, and machine twist injury in 4 patients. The patients had received surgical treatment for 1-5 times (mean, 2.7 times). Bone defects located at the radius in 10 cases, at the ulna in 7 cases, and at the radius and ulna in 2 cases. The mean time of chronic infection was 8.3 months (range, 4-16 months). The mean length of the bone defects after debridement was 3.54 cm (range, 2.2-7.5 cm). Under the guidance of C-arm fluoroscope, the Orthofix unilateral external fixator was used to fix. Distraction was performed at 7-10 days after operation, and X-ray film was taken regularly to detect the osteogenesis. ResultsThe mean external fixation time was 6.5 months (range, 3-12 months), and the mean external fixation index was 1.72 months/cm (range, 1.14-2.15 months/cm). All patients were followed up for 35.4 months on average (range, 24-55 months). The bone union time was 3-11 months (mean, 6 months); and no recurrence of infection was observed. At last follow-up, the mean wrist range of motion (ROM) were 52.78° (range, 42-55°) in flexion and 46.53° (range, 40-60°) in extension; the mean elbow ROM were 139.23° (range, 130-150°) in flexion and 3.57° (range, 0-20°) in extension; and the mean forearm ROM were 76.68° (range, 68-90°) in pronation and 81.75° (range, 72-90°) in supination. ConclusionIlizarov technology for infected forearm nonunion can acquire satisfactory clinical results. Radical debridement is the key to control bone infection.