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find Author "ZHAO Wei." 1 results
  • Study of E-cadherin Antisense Oligodeoxynucleotide on Invasive Ability of Tumor Cells

    【Abstract】ObjectiveTo study the effect of down-regulation of E-cadherin on the invasion ability of tumor cells. MethodsHuman pancreatic carcinoma cell line JHP-1 was treated with E-cadherin antisense oligodeoxynucleotied (ASODN). The immunocytochemistry, Western blot were used to detect the expression and the contents of E-cadherin in the tumor cells, and the invasive ability of tumor cells were evaluated by invasive-MTT assay. Results Treated with E-cadherin ASODN, the expression of E-cadherin on JHP-1 cells were reduced, and the protein contents were decreased as well compared with control groups and ODN group. The invasive ability of JHP-1 cells to the basement membrane was increased (P<0.001) compared with ODN group and control group. ConclusionE-cadherin was related to the invasive ability of tumor cells.

    Release date:2016-09-08 11:52 Export PDF Favorites Scan
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