ObjectiveTo investigate the prevalence and risk factors of sever early childhood caries (SECC) among 3 to 5 years old children of Uyghur and Han in Kashi city, and to provide scientific basis for the establishment of oral hygiene policies for caries prevention and diagnostic among children. MethodsAccording to the basic methods of Third National Oral Health Investigation in 2005, a stratified multistage cluster randomly sampling design was applied. The deciduous caries of 893 Uyghur and Han children aged from three to five in ten kindergartens of Kashi city were clinically examined. Data were collected by questionnaire from their parents, and the result analyzed using SPSS 17.0 software. ResultsThe caries prevalence rate of primary tooth was 74.69% and the total prevalence of SECC was 39.19%. The risk factors for SECC include lower age (OR=1.537, 95% CI 1.132 to 2.086, P=0.006), the more frequencies of drinking coke (OR=1.448, 95% CI 1.008 to 2.080, P=0.045), eating fruits (OR=1.840, 95% CI 1.347 to 2.512, P=0.000), drinking milk (OR=1.794, 95% CI 1.311 to 2.456, P=0.000), and before bedtime eating or after brush eating (OR=1.833, 95% CI 1.199 to 2.802, P=0.005), as well as the higher age of starting brush (OR=2.053, 95% CI 1.448 to 2.910, P=0.000). The protective factors for SECC include the more frequency of brushing (OR=0.612, 95% CI 0.445 to 0.844, P=0.003), and higher household income (OR=0.526, 95% CI 0.423 to 0.654, P=0.000). ConclusionThere is a high prevalence of SECC in Kashi city. It is necessary to strengthen the prevention and education activities, and perform early preventive works for caries disease of children.
ObjectiveTo investigate the oral health status of three to five year-old Uygur and Han children in Yining region of Xinjiang Uygur Autonomous Region, so as to provide scientific basis of corresponding countermeasures. MethodsA stratified, multistage and cluster sampling method was used to select 1 000 three to five year-old preschoolers from urban and rural districts in Yining region of Xinjiang Uygur Autonomous Region. The dental caries rate and oral health situation of included children by age, sex, nationality, and region were analyzed. ResultA total of 965 children were included. The response rate was 96.5%. The prevalence of deciduous dental caries was 81.24% with the mean DMFT score of 4.44. There were significant differences in levels of caries among different age groups, the prevalence of dental caries and mean DMFT score increased gradually as the children were growing up (P<0.05). The rate of filling teeth was 1.66%, and untreated caries was 98.34%. Maxillary deciduous central incisors and mandibular deciduous molar were most prone to decay. There were significant different oral hygiene status and malocclusion levels between the Uygur and Han, urban and rural districts, different age groups (all P values <0.05). ConclusionThe oral health status among three to five year-old preschoolers is not optimistic in Yining region of Xinjiang Uygur Autonomous Region. Integrated treatment and preventive programs are urgently needed.
ObjectiveTo systematically review the healing rate of single-versus multiple-visit root canal treatment for teeth with infected root canals. MethodsPubMed, EMbase, EBSCO, MEDLINE, The Cochrane Library (Issue 3, 2015), CNKI, VIP, CBM and WanFang Data databases were searched from inception to March 2015, to collect randomized controlled trials (RCTs) concerning single-versus multiple-visit root canal treatment for teeth with infected root canals. Two reviewers independently screened literature, extracted data, and assessed the risk of bias of included studies. Then meta-analysis was performed using RevMan 5.3.5 software. ResultsA total of 9 RCTs involving 1 146 teeth were included. The results of meta-analysis showed that:the healing rates were 88.98% in the single-visit group, and 85.61% in the multiple-visit group, respectively. There were no significant difference between two groups (OR=1.36, 95%CI 0.95 to 1.96, P=0.09). ConclusionCurrent evidence shows that, the healing rate of single- and multiple-visit root canal treatment is similar for infected root canals. Due to the limited quantity of included studies, more high quality studies are needed to validate the above conclusion.
ObjectiveTo systematically evaluate the clinical efficacy of systemic antibiotic combined with non-surgical periodontal therapy for aggressive periodontitis. MethodsWe searched PubMed, EMbase, The Cochrane Library, WanFang Data, CBM, VIP and CNKI databases from inception to January, 2016, to collect randomized controlled trials (RCTs) about non-surgical periodontal therapy combined with systemic antibiotics for aggressive periodontitis. Two reviewers independently screened literature, extracted data and evaluated the bias risk of included studies. Then meta-analysis was performed using RevMan 5.3 software. ResultsA total of 8 RCTs involving 236 patients were included. The results of meta-analysis showed, compared with non-surgical periodontal therapy alone, non-surgical periodontal therapy combined with systemic antibiotics showed a significant additional probing depth reduction at 3-, 6- and 12 months follow-up (MD=0.33, 95%CI 0.25 to 0.41, P<0.00001; MD=0.53, 95%CI 0.44 to 0.62, P<0.00001; MD=0.52, 95%CI 0.23 to 0.81, P=0.0004), and a significant clinical attachment gain at 3-, 6- and 12 months follow-up (MD=0.43, 95%CI 0.30 to 0.56, P<0.00001; MD=0.44, 95%CI 0.33 to 0.55, P<0.00001; MD=0.43, 95%CI 0.20 to 0.65, P=0.0002). ConclusionCurrent evidence shows that the treatment of patients with aggressive periodontitis, systemic antibiotic (Metronidazole and Amoxicillin) combined with non-surgical periodontal therapy has a significant additional effect than non-surgical therapy alone. However, because of the limitation of quality and quantity of included studies, the above conclusion still needs to be further proved by conducting more high-quality and large-scale RCTs.
ObjectiveTo assess the long-term effectiveness and safety of autologous bone marrow mononuclear cells (BM-MNC) transplantation in the treatment of critical diabetic lower arteriosclerosis obliterans (ASO). MethodsBetween January 2007 and January 2010, 61 patients with critical diabetic lower ASO were treated with standard medical therapies in 29 cases (control group) or with standard medical therapies and autologous BM-MNC transplantation in 32 cases (treatment group). There was no significant difference in gender, age, disease duration, Fontatine stage, glucose (GLU), triglyceride (TG), total cholesterol (CHOL), low-density lipoprotein-cholesterol (LDL-C), hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and diastolic blood pressure (DBP) between 2 groups (P>0.05). The endpoints were overall survival (OS) and amputation-free survival (AFS). The risk indexes for ASO were observed and compared between 2 groups before and after treatments. ResultsThe patients were followed up 2-36 months, and no malignant tumor occurred. The OS rate, OS time, AFS rate, and AFS time were 82.76% (24/29), (32.31±9.08) months, 37.50% (9/24), and (21.28±13.35) months in the control group and were 78.13% (25/32), (32.47±6.96) months, 68.00% (17/25), and (28.38±9.48) months in the treatment group;all indexes showed no significant differences (P>0.05). OS rate, OS time, AFS rate, and AFS time showed no significant differences between 2 groups at the other time (P>0.05) except AFS time at 1 year, which was significantly short in the control group than the treatment group (t=2.806, P=0.007). At the endpoint of follow-up, the indexes of GLU, TG, CHOL, LDL-C, HbA1c, SBP, and DBP showed no significant differences between before and after treatments and between 2 groups (P>0.05) in 49 survival patients (24 in control group and 25 in treatment group). ConclusionAutologous BM-MNC transplantation is safe and effective in the treatment of critical diabetic lower ASO, which can significantly improve AFS rate and prolong AFS time with no risks.