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find Author "ZHOU Shubing" 1 results
  • Preventive Effects of Glycine on Rat Sinusoidal Endothelial Cells Injury after Hepatic Warm IschemiaReperfusion

    ObjectiveTo investigate the protective effects of glycine on rat sinusoidal endothelial cells (SECs) after hepatic warm ischemiareperfusion and its mechanism.MethodsSeventytwo male SD rats were randomly divided into the normal control,ischemiareperfusion,glycine plus strychnine treated and glycine treated groups. The changes of endothelin (ET),hyaluronic acid (HA),tumor necrosis factorα (TNFα) content and alanine aminotransterase (ALT), superoxide dismutase (SOD) activity as well as morphology of SECs under light microscope were observed at the time point 1,3,24 h after hepatic reperfusion. The effects of glycine on the above parameters were also observed. ResultsThe group using glycine treated, the abnormal changes of all above parameters were improved remarkably (P<0.01 or P<0.05). Strychnine can antagonize these effects partly.ConclusionGlycine can prevent the injury to rat SECs after hepatic warm ischemiareperfusion.It most likely acts through glycine receptor on SECs and Kupffer cells.

    Release date:2016-08-28 04:49 Export PDF Favorites Scan
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