ObjectiveTo discuss diagnosis and treatment of peritoneal metastasis from colorectal cancer. MethodThe literatures about methods of diagnosis and treatment of peritoneal metastasis from colorectal cancer at home and abroad were reviewed. ResultsDiagnosis methods of peritoneal metastasis from colorectal cancer were constantly updated, mainly including hematology, immunology, and imaging methods. Prophylactic treatment mainly included infusion chemotherapy and postoperative systemic chemotherapy. The resection of primary tumor and cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy were performed for the patients diagnosed as peritoneal metastasis from colorectal cancer. ConclusionsThere is still no gold standard for diagnosis of peritoneal metastasis from colorectal cancer. Comprehensive assessment and comprehensive treatment would be performed, so that effect of treatment might be improved.
Objective To investigate the clinical and pathological factors associated with simultaneity peritoneal metastasis of colorectal cancer. Methods Clinical data of 1 593 patients with simultaneity peritoneal metastasis of colorectal cancer who treated in Suqian People’s Hospital and Nanjing Drum Tower Hospital from 2010-2014 were collected to analyze the risk factors of simultaneity peritoneal metastasis of colorectal cancer. Results There were 40 patients (2.5%) suffered form simultaneity peritoneal metastasis of the 1 593 patients with colorectal cancer. The result of univariate analysis showed that, age, diameter of tumor, level of carcino-embryonic antigen (CEA), level of CA19-9, level of CA-125, T staging, differentiation, pathological type, and combining with diabetes were risk factors of simultaneity peritoneal metastasis of colorectal cancer, that incidence rates of simultaneity peritoneal metastasis in patients with ≥ 65 years old, diameter ≥ 5 cm, increase of CEA, CA19-9, and CA-125, later staging of T staging, poorly differentiated, signet ring cell carcinoma/mucinous adenocarcinoma, and combining with diabetes were higher (P<0.05). The result of logistic regression showed that, level of CA19-9, level of CA-125, T staging, combining with diabetes, differentiation, and pathological type were the risk factors of simultaneity peritoneal metastasis of colorectal cancer, that incidence rates of simultaneity peritoneal metastasis in patients with increase of CEA and CA-125, later staging of T staging, poorly differentiated (compared with well differentiated), mucinous adenocarcinoma (compared with adenocarcinoma), and combining with diabetes were higher (P<0.05). Conclusion Increase of CEA and CA-125, T staging, poorly differentiated, mucinous adenocarcinoma, and combining with diabetes are independent risk factors for simultaneity peritoneal metastasis of colorectal cancer.