【摘要】 目的 观察聚明胶肽注射液和羟乙基淀粉（130/0.4）氯化钠注射液对创伤失血性休克患者的临床治疗效果。 方法 将2006年6月-2008年10月创伤失血性休克患者32例随机分为聚明胶肽组和羟乙基淀粉组，每组16例。抢救时除采用止血、扩容、纠酸等综合措施外，分别输入聚明胶肽注射液和羟乙基淀粉（130/0.4）氯化钠注射液1 500 mL。两组均监测血压、尿量和血气分析指标，比较两组指标恢复正常以及所需的时间。 结果 聚明胶肽组与羟乙基淀粉组上述指标恢复正常及所需的时间无差异，两组生存率、致残率及并发症均无差异。 结论 聚明胶肽注射液用于创伤失血性休克的疗效与羟乙基淀粉（130/0.4）氯化钠注射液相当。【Abstract】 Objective To observe the clinical effects of polygeline injection and hydroxyethyl starch(130/0.4) NaCl injection (HES)on the traumatic hemorrhagic shock. Methods A total of 32 patients with traumatic hemorrhagic shock were randomly divided into polygeline injection group and HES group,with 16 patients in each. The same measures such as hemstasis, expanding blood volume, correction of acid base disturbance and so on were adopted in the both groups. The patients in the polygeline injection group and HES group were respectively treated with polygeline injection and HES NaCl injection in a dose of 1500 mL by intravenous infusion. The time from injection to the recovery of BP, urinary output, and blood gas to normal level was recorded. Results BP, urinary output, and blood gas were all improved significantly, there was no significant difference between the two groups (Pgt;0.05). Conclusion The clinical effect of polygeline injection on stabilizing BP and improving microcirculation appears comparable to that of HES.