Although the current postgraduate education system is gradually improving, there are still some problems in the education mode of postgraduate, especially medical postgraduates in China. The current education mode lacks the ability to stimulate students’ potential to the greatest extent and cultivate talents who can develop comprehensively and focus on a certain direction, and lacks the ability to cultivate “four-faceted” scientific and technological workers who can advance to the breadth and depth of science. In view of the above problems, this paper explores the postgraduate education mode based on the close clinical-basic medicine combination on the basis of the tutor system, and summarizes the successful experience obtained in the process of practical teaching, aiming to provide a high quality reference for the medical postgraduate education.