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find Keyword "evoked potential" 32 results
  • Changes of Somatosensory Evoked Potentials During Graded Spinal Cord Ischemia/reperfusion Injury in Rabbits

    Objective To investigate the relationship between graded spinal cord ischemia/reperfusion injury and somatosensory evoked potentials(SEP),neurologic function score(NFS)and the histopathological changes of spinal cord. Methods Forty rabbits were randomized and equally divided into 4 groups: shamoperation group, ischemia for 30min, 45min and 60min groups. The spinal cord ischemiareperfusion injury model was created by occlusion of the abdominal aorta in rabbits. SEP was monitored before ischemia,5,10minutes after ischemia, 15, 30 minutes, 1,2, 24 and 48 hours after reperfusion. NFS was evaluated at 6,12,24 and 48 hours after reperfusion.The pathological changes of spinal cord were observed after reperfusion 48 hours. Results The pathological characters with mild,moderate and severe spinal cord ischemia/reperfusion injury could be simulated by declamping after 30, 45 and 60 minutes infrarenal aorta crossclamping. SEP amplitude returned to normal after reperfusion 15 minutes(Pgt;0.05)and SEP latency returned to normal after reperfusion 30 minutes(Pgt;0.05)during mild spinal cord ischemia/reperfusion injury.SEP amplitude returned to normal after reperfusion 30 minutes(Pgt;0.05)and SEP latency returned to normal after reperfusion 60 minutes(Pgt;0.05)during moderate spinal cord ischemia/reperfusion injury. SEP latency increased and SEP amplitude decreased during severe spinal cord ischemia/reperfusion injury,compared with other groups, there were significant differences in SEP latency and SEP amplitude by clamping the infrarenal aorta for 60min(Plt;0.01). With graded spinal cord ischemia/reperfusion injury, compared with shamoperation group, spinal cord ischemiareperfusion groups had significant differences in NFS(Plt;0.01). Conclusion SEP is much quicker in the recovery of amplitude than latency during spinal cord ischemia/reperfusion. SEP is a sensitive and accurate index for spinal cord function during ischemia/reperfusion injury. SEP monitoring spinal cord ischemia/reperfusion injury during operation provides experimental basis for clinical application.

    Release date:2016-08-30 06:16 Export PDF Favorites Scan
  • FUNCTIONAL EVALUATION OF ELECTRICAL-INJURY NERVE USING SOMATOSENSORY EVOKED POTENTIAL TECHNIQUE

    OBJECTIVE: To investigate the characteristics and the pathologic classification of electrical-injury nerve using somatosensory evoked potential(SEP) technique. METHODS: SEP were detected and evaluated in 12 cases with electrical-injury nerve during operation, electrical stimulation was commenced from distal side of nerve where the structure of nerve looks normal under operating microscope, up to proximal side until evoking out a stable SEP predeterminate virtual value. Pathological examination and the following functional evaluation were compared with the values of SEP. RESULTS: At the site of nerve looking normal under operating microscope, perineurium appears normal or slightly thicken. But there are obvious fibrosis and fibrotic proliferation between fascicular and intrafascicular. Vessel plexus is not seen. At SEP stabilizely evoked site, nervous construction is normal, there are visible interfascicular vessel plexus and connective tissue appears loose. Comparing SEP values with pathological section, amplitude and latency of SEP is positively correlative with the quality of nerve. Eight cases repaired with SEP technique to select the anastomosis site for nerve transplantation were followed up, two-point discrimination reached grade III (America hand surgery association criterion) within 62.5% cases. CONCLUSION: SEP technique is valuable method for functional evaluation of electrical- injury nerve which has a complicated pathology. The pathology of electrical-injury nerve can be classified into 4 types, type A: fibrosis of nerve; type B: nerve looking normal under operation microscope, perineurium appears thicken, and there are obvious fibrosis and fibrotic proliferation between fascicular and intrafascicular, vessel plexus is rarely to see; type C: nerve looks normal, lymphocyte infiltration exists and it is obvious that there are many physalis-like, retrogressive construction in the section; type D: nervous construction is normal, there are visible interfascicular vessel plexus, and connective tissue appears loose, SEP always can be stably evoked.

    Release date:2016-09-01 10:28 Export PDF Favorites Scan
  • THE ELECTRONNEUROGRAM MANIFESTATION OF ACUTE TRAUMATIC CERVICAL SPINAL CORD INJURY WITHOUT FRACTURE OR DISLOCATION

    In order to investigate the clinical significance of electron-neurogram for evaluating the degree and prognosis of acute traumatic cervical spinal cord injury without fracture or dislocation, electron-neurogram and sensory evoked potential (SEP) of the upper limbs in 4 such cases were recorded from the 3rd to 30th day after the injury. The results showed SEP and MEP could be obtained from every nerve in both upper limbs, and continous monitoring of SEP and MEP could provide valuable data to judge the degree and prognosis of the injury in spinal cord.

    Release date:2016-09-01 11:07 Export PDF Favorites Scan
  • HISTOLOGICAL AND ELECTROPHYSIOLOGIC CHANGES OF INJURY OF DORSAL ROOT GANGLIA

    Injury of dorsal root ganglia (DRG) may cause sensory and motor dysfunction. In order to investigate the changes of somato-sensory evoked potential (SEP) and histological characteristics of DRG in different causes and different periods of injury, fifty-two rabbits were chosed to build the models. The rabbits were divided into 4 groups: Control group (n = 4); mechanical compressing group (n = 16); inflammatory injury group (n = 16); and treatment group (2% lidocaine with hydroprednisone was administered locally, n = 16). After one to eight weeks, SEP was determined and samples of DRG were obtained to observe the histological and ultrastructural changes every week. The result showed that the gap junction of microvascular endothelium in DRG had been destroyed by the mechanical compression was the major cause of the vessel permeability increasing. The increasing of endothelial pinocytic vesicles transportation and widening of endothelial gap junction were the main causes of inflammatory irritation of DRG. The local infiltration with 2% lidocaine and hydroprednisone could obviously ameliorate inflammatory injury in DRG.

    Release date:2016-09-01 11:07 Export PDF Favorites Scan
  • RECOVERY OF MOTOR FUNCTION OF SPINAL CORD WITH EMBRYONIC SPINAL CORD GRAFT IN ADULT RAT

    The capacity of embryonic spinal cord tissue in the repair of injured structure of spinal cord has been noted for years. In order to investigate the embryonic spinal cord graft in the repair of motor function of injured spinal cord, the embryonic spinal cord tissue was transplanted to the hemisection cavity in spinal cord in adult rat. One hundred adult Wistar Rats were used to simulate the hemisectional injury of spinal cord by drilling 2-3 mm cavity in lumbar enlargement. Sixty rats were treated with rat embryonic spinal cord tissue grafting while the other forty were chosen as control. The outcome was evaluated according the combined behavioural score (CBS) and motor evoked potential (MEP) in the 1, 2, 4 and 12 weeks. The grafting group was superior to the control as assessed by CBS (P lt; 0.05), especially within 4 weeks. (P lt; 0.01). The restoration of the latent peak of early wave(P1, N1) was better in the grafting group, too. This suggested that embryonic spinal cord graft could improve the recovery of motor function of injured spinal cord in adult rat. The effect of the embryonic spinal cord tissue graft might be concerned with its secretion of several kinds of neurotrophic factors, nerve growth factor, nerve transmitted factor, or adjustment of hormone.

    Release date:2016-09-01 11:09 Export PDF Favorites Scan
  • The symmetry of multifocal visual evoked potential between both eyes in normal subjects

    Objective To analyze the symmetry of multifocal visual evoked potential (mfVEP) between both eyes in normal subjects. Methods The monocular mfVEP of both eyes in thirty-six normal subjects (72 eyes) was tested with VERIS Science 4.0. The stimulus was the pattern reversal dart array consisted of 60 sectors each included 16 black-white reverse patterns. The visual stimulation was controlled by the binary pseudo-random m-sequences and subtended approximately 25 degrees. Results There existed no statistically significant difference of P1 latencies and amplitudes between correspondent quadrant visual field of both eyes. The data difference of the ipsilateral quadrant visual fields was greater than those of the correspondent quadrant visual field. The comparison among four quadrant visual fields in right eye or left eye each showed that there was statistically significant difference of P1 latencies between the superionasal quadrant visual field and inferiotemporal or inferionasal quadrant visual fields. Conclusions The symmetry of normal mfVEP is more dominant in retina than that in visual cortex. (Chin J Ocul Fundus Dis, 2006, 22: 42-44)

    Release date:2016-09-02 05:51 Export PDF Favorites Scan
  • THE STEADY-STATE FLASH VEP IN OPTIC NEUROPATHY

    Steady-state flsash visual evoked potentials (SFVEPs) of 30 Hz were recorded for 46 normal subjects (89 eyes )and 35 patients (51 eyes )with optic neuropathy. The visual acuities of 58.8%affected eyes were less than 0.1. The recorded waveforms were analyzed by discrete Foruier transform (DTF). The amplitudes and phases of fundamental response component and second harmonic were abstracted as characteristic values of the waveform.The total abnormal ratio was 80. 4%. The abnormal types showed the reduced amplitudes,reduced amplitude with phase change, the phases changes, and flat wave. The advantages of SFVEPs in clinical application were discussed. (Chin J Ocul Fundus Dis,1994,10:213-215)

    Release date:2016-09-02 06:34 Export PDF Favorites Scan
  • BINOCULAR DISPARITY IN VEP RELATE TO STEREOPSIS

    We have utilized the binocular flat and stereoscopic pattern to record visual evoked potentials (VEP) in normal and strabismic subjects. The aim was to find an electrophysiological correlation with the degree of binocular interaction in these subjects.The perception as tridimensional or flat derived from the disparity obtained with polaroid filters placed in front of the eyes. In normal subjects, the results demonstrated a significant increase of VEP amplitude during tridimensional perception of the pattern. In strabismic subjects the electrophysiological response were not correlated with the binocular conditions. The findings in the present study suggest that the binocular disparity in VEP examination is a useful technique and a better objective index for evaluating stereoscopic function than the psychophysical technique. (Chin J Ocul Fundus Dis,1992,8:10-13)

    Release date:2016-09-02 06:36 Export PDF Favorites Scan
  • Regulations of VEP Changes in 30 Patients with Multiple Sclerosis

    Objective To study the regulations of visual evoked potential(VEP) changes in 30 patients with multiple sclerosis (MS). Methods VEP were performed in 30 MS patients,and the results were compared with normal subjects. Results The abnormality rate of VEP were 76.7%. 82.6% of patients with abnormal VEP showed clinical visual symptoms; 17.4% among those patients have no clinical visual symptoms. Conclusion  The rate of VEP abnormal in MS patients is more high. It may help more in the diagnosis of MS.

    Release date:2016-09-07 02:11 Export PDF Favorites Scan
  • Analysis and Management of Blood Pressure on Intraoperative Cortex Somatosensory Evoked Potential in the Surgery of Severe Scoliosis

    ObjectiveTo investigate the influence and management of blood pressure on intraoperative cortex somatosensory evoked potential (CSEP) in the surgery of severe scoliosis. MethodsFrom June 2009 to March 2012, CSEP monitoring during surgery of severe scoliosis were performed on 43 patients, in whom 4 had abnormal CSEP while blood pressure decline. There were 2 males and 21 females. The average age was 16.1 years. The average preoperative Cobb angle was 96.1° (88.7-107.5°). Latency and amplitude of cortical potentials were observed with the value of the latency extension more than 10% and peak amplitude reduction more than 50% defined as abnormality. The arterial blood pressure (ABP) was used to evaluate the intraoperative blood pressure. ResultThe incidence rate of bilateral CSEP wave abnormalities after blood pressure decline was 9.3% in the surgery of severe scoliosis. One case of CSEP abnormality occurred during the installing of pedicle screws; two cases during the Smith-Petersen osteotomy, and one case during the bone graft after correction. With the ABP dropping to about 92/57 mm Hg (1 mm Hg=0.133 kPa), the amplitude decreased 80% in 24-33 minutes. After the ABP increased to 113/75 mm Hg by treatment, the index was backed up normally in 5-10 minutes. There was no neurological complication after surgery. ConclusionA high incidence rate and significantly decreased amplitude of CSEP abnormality after blood pressure decline in the surgery of severe scoliosis are found. Intraoperative stable blood pressure should be maintained for patients with severe scoliosis. When the amplitude of CSEP decreases followed with blood pressure decline, blood pressure should be actively corrected by treatment, so that the CSEP may get back to normal as soon as possible.

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