Postmenopausal osteoporosis is a type of osteoporosis with high bone transformation rate, caused by a decrease of estrogen in the body, which is a systemic bone disease characterized by decreased bone mass and increased risk of fracture. In recent years, as a kind of non-pharmacologic treatment of osteoporosis, defined by whole-body vibration less than 1 g (g = 9.81 m/s2), low magnitude whole-body vibration is widely concerned, mainly because of its small side effects, simple operation and relative safety. Studies have shown that low magnitude whole-body vibration can improve bone strength, bone volume and bone density. But a lot of research found that, the therapeutic effects of low magnitude whole-body vibration are different depending on ages and hormone levels of subjects for animal models or human patients. There has been no definite vibration therapy can be applied to each subject so far. Studies of whole-body and cellular level suggest that low magnitude whole-body vibration stimulation is likely to be associated with changes of hormone levels and directed differentiation of stem cells. Based on the analysis of related literature in recent years, this paper made a review from vibration parameters, vibration effects and the mechanisms, to provide scientific basis and clinical guidance for the treatment of postmenopausal osteoporosis with low magnitude whole-body vibration.
Due to the aging population intensifies, the number of people suffering from mild cognitive impairment (MCI) or dementia is expected to increase, which may lead to a series of public health and social health problems. In the absence of drugs to prevent the transformation of MCI into dementia, it is urgent to find effective non-pharmacological therapies to delay the progress of cognitive impairment. This article will review the diagnosis of MCI and the research progress of non-pharmacological therapies, focusing on the non-pharmacological therapies related to MCI in recent years, including exercise intervention, cognitive intervention, physical and mental exercise, dietary intervention, electroacupuncture, repeated transcranial magnetic stimulation, and multi-component intervention, in order to provide an effective treatment for preventing or delaying the progression of MCI to dementia.
Objective To evaluate the effect of different non-pharmacological interventions on the cognitive function of elderly people with cognitive decline, and provide useful reference for improving cognitive function of the elderly. Methods Computer searches of PubMed, Embase, the Cochrane Library, Web of Science, China National Knowledge Infrastructure, VIP Database, Wanfang Data, and China Biomedical Literature Database for randomized controlled trials on non-pharmacological interventions for aged adults with cognitive decline were conducted, all with a search time frame from database inception to October 9th, 2023. Literature screening, information extraction and bias risk assessment using RevMan 5.4 software were performed by two evaluators independently, and Stata 16.0 and R 4.3.0 software was used for network meta-analysis. Results A total of 27 articles involving 2149 elderly patients and 7 intervention protocols were included. Among the 27 articles, 8 were graded A and 19 were graded B for quality. The network meta-analysis revealed that, using the Montreal Cognitive Assessment (MoCA) as the evaluating metric, virtual reality [mean difference (MD)=6.01, 95% confidence interval (CI) (0.90, 10.75)], cognitive training [MD=4.99, 95%CI (0.56, 9.12)], and exercise training [MD=3.88, 95%CI (0.47, 7.27)] were better than community services, respectively (P<0.05), and exercise training was also better than conventional care [MD=3.05, 95%CI (0.92, 5.12), P<0.05]; using the Mini-Mental State Examination (MMSE) as the evaluation indicator, multimodal exercise [MD=3.00, 95%CI (0.89, 4.96)], cognitive training [MD=2.50, 95%CI (0.27, 4.82)], traditional Chinese exercise [MD=2.30, 95%CI (0.34, 4.28)], psychotherapy [MD=1.76, 95%CI (0.56, 2.96)], and exercise training [MD=1.36, 95%CI (0.18, 2.59)] were better than conventional care, respectively (P<0.05), and multimodal exercise [MD=3.32, 95%CI (0.62, 5.81)], cognitive training [MD=2.82, 95%CI (0.75, 4.90)], and traditional Chinese exercise [MD=2.63, 95%CI (0.08, 5.13)] were also better than community service, respectively (P<0.05). The results of the cumulative probability ranking showed that virtual reality had the highest probability of being the best intervention in terms of improving MoCA metrics (0.863), and multimodal exercise had the highest probability of being the best intervention in terms of improving MMSE metrics (0.868). Conclusion Using MoCA as an evaluation indicator, virtual reality may be the best non-pharmacological intervention; using MMSE as an evaluation indicator, multimodal exercise may be the best non-pharmacological intervention.
Objective To retrieve and summarize evidence of non-pharmacological interventions for sleep disorders in patients with osteoarthritis (OA), and to organize and evaluate the extracted evidence to provide evidence-based interventions for sleep disorders in patients with OA. Methods The relevant literature on non-pharmacological interventions for sleep disorders in patients with OA in BMJ Best Practice, UpToDate, JBI evidence-based healthcare center database, National Institute for Health and Clinical Excellence, Registered Nurses’ Association of Ontario, Guidelines International Network, Medlive guidelines network, Cochrane Library, PubMed, Web of Science, China National Knowledge Infrastructure and Wanfang was systematically searched. The search deadline was June 30th, 2024. The retrieved results were integrated and analyzed to form evidence of non pharmacological interventions for sleep disorders in patients with OA. Results A total of 13 articles were included, including 1 evidence report, 5 guidelines, 2 expert consensus papers, 3 systematic reviews, and 2 randomized controlled trials. The summarized evidence involves six aspects of sleep screening, specialist visits, assessment tools, cognitive behavioral therapy, exercise therapy, and other measures, totaling 20 pieces of evidence. Conclusion Non-pharmacological interventions for sleep disorders of patients with OA include multiple aspects, and this evidence can provide theoretical basis for developing intervention plans for sleep disorder of patients with OA, thereby improving their sleep quality and enhancing quality of life.