Malignant peritoneal mesothelioma is a very rare serous malignant tumor, which often manifests as multiple soft tissue masses in peritoneum and omentum, most of which are accompanied by ascites. In this study, a case of peritoneal malignant mesothelioma confirmed by pathological examination was presented. The case was rarely confined to the perihepatic peritoneum and grew into the liver. Without ascites, it was easy to be confused with intrahepatic lesions. Through case analysis, on the one hand, the MRI manifestations of malignant peritoneal mesothelioma are displayed. On the other hand, the main points of differentiation between extrahepatic and intrahepatic origin lesions are discussed, so as to improve the understanding and differential diagnosis ability of this disease.